Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia

Hans Rasmussen; David Erritzoe; Rune Andersen; Bjorn H Ebdrup; Bodil Aggernaes; Bob Oranje; Jan Kalbitzer; Jacob Madsen; Lars Hageman Pinborg; William Baaré; Claus Svarer; Henrik Lublin; Gitte M Knudsen; Birte Yding Glenthøj

doi:http://dx.doi.org/10.1001/archgenpsychiatry.2009.176

Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia

Hans Rasmussen, David Erritzoe, Rune Andersen, Bjorn H Ebdrup, Bodil Aggernaes, Bob Oranje, Jan Kalbitzer, Jacob Madsen, Lars Hageman Pinborg, William Baaré, Claus Svarer, Henrik Lublin, Gitte M Knudsen, Birte Yding Glenthøj

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

102 Citationer (Scopus)

Abstract

Postmortem investigations and the receptor affinity profile of atypical antipsychotics have implicated the participation of serotonin(2A) receptors in the pathophysiology of schizophrenia. Most postmortem studies point toward lower cortical serotonin(2A) binding in schizophrenic patients. However, in vivo studies of serotonin(2A) binding report conflicting results, presumably because sample sizes have been small or because schizophrenic patients who were not antipsychotic-naive were included. Furthermore, the relationships between serotonin(2A) binding, psychopathology, and central neurocognitive deficits in schizophrenia are unclear.

Originalsprog	Engelsk
Tidsskrift	Archives of General Psychiatry
Vol/bind	67
Udgave nummer	1
Sider (fra-til)	9-16
Antal sider	8
ISSN	0003-990X
DOI	https://doi.org/10.1001/archgenpsychiatry.2009.176
Status	Udgivet - 1 jan. 2010

Adgang til dokumentet

http://dx.doi.org/10.1001/archgenpsychiatry.2009.176

Citationsformater

Rasmussen, H., Erritzoe, D., Andersen, R., Ebdrup, B. H., Aggernaes, B., Oranje, B., Kalbitzer, J., Madsen, J., Pinborg, L. H., Baaré, W., Svarer, C., Lublin, H., Knudsen, G. M., & Glenthøj, B. Y. (2010). Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia. Archives of General Psychiatry, 67(1), 9-16. https://doi.org/10.1001/archgenpsychiatry.2009.176

Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia. / Rasmussen, Hans; Erritzoe, David; Andersen, Rune; Ebdrup, Bjorn H; Aggernaes, Bodil; Oranje, Bob; Kalbitzer, Jan; Madsen, Jacob; Pinborg, Lars Hageman; Baaré, William; Svarer, Claus; Lublin, Henrik; Knudsen, Gitte M ; Glenthøj, Birte Yding.

I: Archives of General Psychiatry, Bind 67, Nr. 1, 01.01.2010, s. 9-16.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Rasmussen, H, Erritzoe, D, Andersen, R, Ebdrup, BH, Aggernaes, B, Oranje, B, Kalbitzer, J, Madsen, J, Pinborg, LH, Baaré, W, Svarer, C, Lublin, H, Knudsen, GM & Glenthøj, BY 2010, 'Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia', Archives of General Psychiatry, bind 67, nr. 1, s. 9-16. https://doi.org/10.1001/archgenpsychiatry.2009.176

Rasmussen, Hans ; Erritzoe, David ; Andersen, Rune ; Ebdrup, Bjorn H ; Aggernaes, Bodil ; Oranje, Bob ; Kalbitzer, Jan ; Madsen, Jacob ; Pinborg, Lars Hageman ; Baaré, William ; Svarer, Claus ; Lublin, Henrik ; Knudsen, Gitte M ; Glenthøj, Birte Yding. / Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia. I: Archives of General Psychiatry. 2010 ; Bind 67, Nr. 1. s. 9-16.

@article{4ba58387092448bc817ff45eeba012b1,

title = "Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia",

abstract = "Postmortem investigations and the receptor affinity profile of atypical antipsychotics have implicated the participation of serotonin(2A) receptors in the pathophysiology of schizophrenia. Most postmortem studies point toward lower cortical serotonin(2A) binding in schizophrenic patients. However, in vivo studies of serotonin(2A) binding report conflicting results, presumably because sample sizes have been small or because schizophrenic patients who were not antipsychotic-naive were included. Furthermore, the relationships between serotonin(2A) binding, psychopathology, and central neurocognitive deficits in schizophrenia are unclear.",

author = "Hans Rasmussen and David Erritzoe and Rune Andersen and Ebdrup, {Bjorn H} and Bodil Aggernaes and Bob Oranje and Jan Kalbitzer and Jacob Madsen and Pinborg, {Lars Hageman} and William Baar{\'e} and Claus Svarer and Henrik Lublin and Knudsen, {Gitte M} and Glenth{\o}j, {Birte Yding}",

year = "2010",

month = jan,

day = "1",

doi = "http://dx.doi.org/10.1001/archgenpsychiatry.2009.176",

language = "English",

volume = "67",

pages = "9--16",

journal = "JAMA Psychiatry",

issn = "2168-622X",

publisher = "The JAMA Network",

number = "1",

}

TY - JOUR

T1 - Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia

AU - Rasmussen, Hans

AU - Erritzoe, David

AU - Andersen, Rune

AU - Ebdrup, Bjorn H

AU - Aggernaes, Bodil

AU - Oranje, Bob

AU - Kalbitzer, Jan

AU - Madsen, Jacob

AU - Pinborg, Lars Hageman

AU - Baaré, William

AU - Svarer, Claus

AU - Lublin, Henrik

AU - Knudsen, Gitte M

AU - Glenthøj, Birte Yding

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Postmortem investigations and the receptor affinity profile of atypical antipsychotics have implicated the participation of serotonin(2A) receptors in the pathophysiology of schizophrenia. Most postmortem studies point toward lower cortical serotonin(2A) binding in schizophrenic patients. However, in vivo studies of serotonin(2A) binding report conflicting results, presumably because sample sizes have been small or because schizophrenic patients who were not antipsychotic-naive were included. Furthermore, the relationships between serotonin(2A) binding, psychopathology, and central neurocognitive deficits in schizophrenia are unclear.

AB - Postmortem investigations and the receptor affinity profile of atypical antipsychotics have implicated the participation of serotonin(2A) receptors in the pathophysiology of schizophrenia. Most postmortem studies point toward lower cortical serotonin(2A) binding in schizophrenic patients. However, in vivo studies of serotonin(2A) binding report conflicting results, presumably because sample sizes have been small or because schizophrenic patients who were not antipsychotic-naive were included. Furthermore, the relationships between serotonin(2A) binding, psychopathology, and central neurocognitive deficits in schizophrenia are unclear.

U2 - http://dx.doi.org/10.1001/archgenpsychiatry.2009.176

DO - http://dx.doi.org/10.1001/archgenpsychiatry.2009.176

M3 - Journal article

VL - 67

SP - 9

EP - 16

JO - JAMA Psychiatry

JF - JAMA Psychiatry

SN - 2168-622X

IS - 1

ER -