Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients

Tina Vilsbøll; T Krarup; S Madsbad; Jens Møller Holst

doi:http://dx.doi.org/10.1007/s00125-002-0878-6

Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients

Tina Vilsbøll, T Krarup, S Madsbad, Jens Møller Holst

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

475 Citationer (Scopus)

Abstract

Glucagon-like-peptide-1 (GLP-1) is strongly insulinotropic in patients with Type II (non-insulin-dependent) diabetes mellitus, whereas glucose-dependent insulinotropic polypeptide (GIP) is less effective. Our investigation evaluated "early" (protocol 1) - and "late phase" (protocol 2) insulin and C-peptide responses to GLP-1 and GIP stimulation in patients with Type II diabetes.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	45
Udgave nummer	8
Sider (fra-til)	1111-9
Antal sider	9
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-002-0878-6
Status	Udgivet - 1 aug. 2002

Adgang til dokumentet

http://dx.doi.org/10.1007/s00125-002-0878-6

Citationsformater

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T1 - Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients

AU - Vilsbøll, Tina

AU - Krarup, T

AU - Madsbad, S

AU - Holst, Jens Møller

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N2 - Glucagon-like-peptide-1 (GLP-1) is strongly insulinotropic in patients with Type II (non-insulin-dependent) diabetes mellitus, whereas glucose-dependent insulinotropic polypeptide (GIP) is less effective. Our investigation evaluated "early" (protocol 1) - and "late phase" (protocol 2) insulin and C-peptide responses to GLP-1 and GIP stimulation in patients with Type II diabetes.

AB - Glucagon-like-peptide-1 (GLP-1) is strongly insulinotropic in patients with Type II (non-insulin-dependent) diabetes mellitus, whereas glucose-dependent insulinotropic polypeptide (GIP) is less effective. Our investigation evaluated "early" (protocol 1) - and "late phase" (protocol 2) insulin and C-peptide responses to GLP-1 and GIP stimulation in patients with Type II diabetes.

U2 - http://dx.doi.org/10.1007/s00125-002-0878-6

DO - http://dx.doi.org/10.1007/s00125-002-0878-6

M3 - Journal article

VL - 45

SP - 1111

EP - 1119

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

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