Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice

Jiusong Sun; Karsten Hartvigsen; Meng-Yun Chou; Yadong Zhang; Galina K Sukhova; Jie Zhang; Marco Lopez-Ilasaca; Cody J Diehl; Niva Yakov; Dror Harats; Jacob George; Joseph L Witztum; Peter Libby; Hidde Ploegh; Guo-Ping Shi

doi:10.1161/CIRCULATIONAHA.109.891887

Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice

Jiusong Sun, Karsten Hartvigsen, Meng-Yun Chou, Yadong Zhang, Galina K Sukhova, Jie Zhang, Marco Lopez-Ilasaca, Cody J Diehl, Niva Yakov, Dror Harats, Jacob George, Joseph L Witztum, Peter Libby, Hidde Ploegh, Guo-Ping Shi

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

80 Citationer (Scopus)

Abstract

Adaptive immunity and innate immunity play important roles in atherogenesis. Invariant chain (CD74) mediates antigen-presenting cell antigen presentation and T-cell activation. This study tested the hypothesis that CD74-deficient mice have reduced numbers of active T cells and resist atherogenesis.

Originalsprog	Engelsk
Tidsskrift	Circulation
Vol/bind	122
Udgave nummer	8
Sider (fra-til)	808-20
Antal sider	13
ISSN	0009-7322
DOI	https://doi.org/10.1161/CIRCULATIONAHA.109.891887
Status	Udgivet - 2010
Udgivet eksternt	Ja

Adgang til dokumentet

10.1161/CIRCULATIONAHA.109.891887

Citationsformater

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title = "Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice",

abstract = "Adaptive immunity and innate immunity play important roles in atherogenesis. Invariant chain (CD74) mediates antigen-presenting cell antigen presentation and T-cell activation. This study tested the hypothesis that CD74-deficient mice have reduced numbers of active T cells and resist atherogenesis.",

author = "Jiusong Sun and Karsten Hartvigsen and Meng-Yun Chou and Yadong Zhang and Sukhova, {Galina K} and Jie Zhang and Marco Lopez-Ilasaca and Diehl, {Cody J} and Niva Yakov and Dror Harats and Jacob George and Witztum, {Joseph L} and Peter Libby and Hidde Ploegh and Guo-Ping Shi",

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language = "English",

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TY - JOUR

T1 - Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice

AU - Sun, Jiusong

AU - Hartvigsen, Karsten

AU - Chou, Meng-Yun

AU - Zhang, Yadong

AU - Sukhova, Galina K

AU - Zhang, Jie

AU - Lopez-Ilasaca, Marco

AU - Diehl, Cody J

AU - Yakov, Niva

AU - Harats, Dror

AU - George, Jacob

AU - Witztum, Joseph L

AU - Libby, Peter

AU - Ploegh, Hidde

AU - Shi, Guo-Ping

PY - 2010

Y1 - 2010

N2 - Adaptive immunity and innate immunity play important roles in atherogenesis. Invariant chain (CD74) mediates antigen-presenting cell antigen presentation and T-cell activation. This study tested the hypothesis that CD74-deficient mice have reduced numbers of active T cells and resist atherogenesis.

AB - Adaptive immunity and innate immunity play important roles in atherogenesis. Invariant chain (CD74) mediates antigen-presenting cell antigen presentation and T-cell activation. This study tested the hypothesis that CD74-deficient mice have reduced numbers of active T cells and resist atherogenesis.

U2 - 10.1161/CIRCULATIONAHA.109.891887

DO - 10.1161/CIRCULATIONAHA.109.891887

M3 - Journal article

C2 - 20697023

SN - 0009-7322

VL - 122

SP - 808

EP - 820

JO - Circulation

JF - Circulation

IS - 8

ER -