Depression and its relationship with poor exercise capacity, BODE index and muscle wasting in COPD

Khaled Al-shair; Rachel Dockry; Brendan Mallia-Milanes; Umme Kolsum; Dave Singh; Jørgen Vestbo

doi:10.1016/j.rmed.2008.11.021

Depression and its relationship with poor exercise capacity, BODE index and muscle wasting in COPD

Khaled Al-shair, Rachel Dockry, Brendan Mallia-Milanes, Umme Kolsum, Dave Singh, Jørgen Vestbo

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

71 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Oct

Originalsprog	Engelsk
Tidsskrift	Respiratory Medicine
Vol/bind	103
Udgave nummer	10
Sider (fra-til)	1572-9
Antal sider	7
ISSN	0954-6111
DOI	https://doi.org/10.1016/j.rmed.2008.11.021 https://doi.org/10.1016/j.rmed.2008.11.021
Status	Udgivet - 2009

Bibliografisk note

Keywords: Aged; Airway Obstruction; Body Mass Index; Depressive Disorder; Dyspnea; Exercise Tolerance; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Prevalence; Pulmonary Disease, Chronic Obstructive; Quality of Life; Questionnaires

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Citationsformater

@article{15b628b0aabb11df928f000ea68e967b,

title = "Depression and its relationship with poor exercise capacity, BODE index and muscle wasting in COPD",

abstract = "BACKGROUND: The prevalence of depression in stable COPD patients varies markedly, possibly because of use of different scales. We aimed to assess depression using 2 different depression scales and to examine the association between depression and poor exercise performance, BODE index and muscle wasting in clinically stable COPD patients. METHODS: 122 stable COPD patients were assessed with the Centre for Epidemiologic Studies Depression Scale (CES-D) and the Brief Assessment Schedule Depression Cards (BASDEC). We also assessed patients with spirometry, bioelectrical impedance analysis, 6-minute walk distance (6MWD), St George's Respiratory Questionnaire (SGRQ) and MRC dyspnoea and Borg scales. RESULTS: The CES-D and BASDEC scales detected almost similar prevalence rates of depression (21% vs 17%) with a Kappa coefficient of 0.68, p<0.0001. The BASDEC scale detected more depression in women and was more closely associated with dyspnoea than the CES-D. COPD severity was associated with depression when using BODE scores but not when GOLD categories were used. Each of the CES-D and BASDEC depression scores were associated with 6MWD after adjusting for FEV1% predicted, gender, age and pack-years (p = <0.0001 and 0.001, respectively). Also, patients with a 6MWD<350 scored significantly higher on both depression scales. Wasted patients appeared to have higher depression scores, but the difference was statistically insignificant. CONCLUSION: The administration of different depression scales may affect some of the characteristics of depressed patients rather than the prevalence rate of depression. Depression was associated with poor exercise performance and BODE index in COPD.",

author = "Khaled Al-shair and Rachel Dockry and Brendan Mallia-Milanes and Umme Kolsum and Dave Singh and J{\o}rgen Vestbo",

note = "Keywords: Aged; Airway Obstruction; Body Mass Index; Depressive Disorder; Dyspnea; Exercise Tolerance; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Prevalence; Pulmonary Disease, Chronic Obstructive; Quality of Life; Questionnaires",

year = "2009",

doi = "10.1016/j.rmed.2008.11.021",

language = "English",

volume = "103",

pages = "1572--9",

journal = "Respiratory Medicine",

issn = "0954-6111",

publisher = "Elsevier",

number = "10",

}

TY - JOUR

T1 - Depression and its relationship with poor exercise capacity, BODE index and muscle wasting in COPD

AU - Al-shair, Khaled

AU - Dockry, Rachel

AU - Mallia-Milanes, Brendan

AU - Kolsum, Umme

AU - Singh, Dave

AU - Vestbo, Jørgen

N1 - Keywords: Aged; Airway Obstruction; Body Mass Index; Depressive Disorder; Dyspnea; Exercise Tolerance; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Prevalence; Pulmonary Disease, Chronic Obstructive; Quality of Life; Questionnaires

PY - 2009

Y1 - 2009

N2 - BACKGROUND: The prevalence of depression in stable COPD patients varies markedly, possibly because of use of different scales. We aimed to assess depression using 2 different depression scales and to examine the association between depression and poor exercise performance, BODE index and muscle wasting in clinically stable COPD patients. METHODS: 122 stable COPD patients were assessed with the Centre for Epidemiologic Studies Depression Scale (CES-D) and the Brief Assessment Schedule Depression Cards (BASDEC). We also assessed patients with spirometry, bioelectrical impedance analysis, 6-minute walk distance (6MWD), St George's Respiratory Questionnaire (SGRQ) and MRC dyspnoea and Borg scales. RESULTS: The CES-D and BASDEC scales detected almost similar prevalence rates of depression (21% vs 17%) with a Kappa coefficient of 0.68, p<0.0001. The BASDEC scale detected more depression in women and was more closely associated with dyspnoea than the CES-D. COPD severity was associated with depression when using BODE scores but not when GOLD categories were used. Each of the CES-D and BASDEC depression scores were associated with 6MWD after adjusting for FEV1% predicted, gender, age and pack-years (p = <0.0001 and 0.001, respectively). Also, patients with a 6MWD<350 scored significantly higher on both depression scales. Wasted patients appeared to have higher depression scores, but the difference was statistically insignificant. CONCLUSION: The administration of different depression scales may affect some of the characteristics of depressed patients rather than the prevalence rate of depression. Depression was associated with poor exercise performance and BODE index in COPD.

AB - BACKGROUND: The prevalence of depression in stable COPD patients varies markedly, possibly because of use of different scales. We aimed to assess depression using 2 different depression scales and to examine the association between depression and poor exercise performance, BODE index and muscle wasting in clinically stable COPD patients. METHODS: 122 stable COPD patients were assessed with the Centre for Epidemiologic Studies Depression Scale (CES-D) and the Brief Assessment Schedule Depression Cards (BASDEC). We also assessed patients with spirometry, bioelectrical impedance analysis, 6-minute walk distance (6MWD), St George's Respiratory Questionnaire (SGRQ) and MRC dyspnoea and Borg scales. RESULTS: The CES-D and BASDEC scales detected almost similar prevalence rates of depression (21% vs 17%) with a Kappa coefficient of 0.68, p<0.0001. The BASDEC scale detected more depression in women and was more closely associated with dyspnoea than the CES-D. COPD severity was associated with depression when using BODE scores but not when GOLD categories were used. Each of the CES-D and BASDEC depression scores were associated with 6MWD after adjusting for FEV1% predicted, gender, age and pack-years (p = <0.0001 and 0.001, respectively). Also, patients with a 6MWD<350 scored significantly higher on both depression scales. Wasted patients appeared to have higher depression scores, but the difference was statistically insignificant. CONCLUSION: The administration of different depression scales may affect some of the characteristics of depressed patients rather than the prevalence rate of depression. Depression was associated with poor exercise performance and BODE index in COPD.

U2 - 10.1016/j.rmed.2008.11.021

DO - 10.1016/j.rmed.2008.11.021

M3 - Journal article

C2 - 19560330

SN - 0954-6111

VL - 103

SP - 1572

EP - 1579

JO - Respiratory Medicine

JF - Respiratory Medicine

IS - 10

ER -