Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Journal of Nuclear Medicine |
| Vol/bind | 50 |
| Udgave nummer | 12 |
| Sider (fra-til) | 1987-92 |
| Antal sider | 5 |
| ISSN | 0161-5505 |
| DOI | |
| Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Aged; Female; Humans; Male; Middle Aged; Perfusion Imaging; Pulmonary Artery; Pulmonary Embolism; Pulmonary Ventilation; Radiation Dosage; Sensitivity and Specificity; Time Factors; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray ComputedAdgang til dokumentet
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Detection of pulmonary embolism with combined ventilation-perfusion SPECT and low-dose CT: head-to-head comparison with multidetector CT angiography. / Gutte, Henrik; Mortensen, Jann; Jensen, Claus Verner; Johnbeck, Camilla Bardram; von der Recke, Peter; Petersen, Claus Leth; Kjaergaard, Jesper; Kristoffersen, Ulrik Sloth; Kjaer, Andreas.
I: Journal of Nuclear Medicine, Bind 50, Nr. 12, 2009, s. 1987-92.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Detection of pulmonary embolism with combined ventilation-perfusion SPECT and low-dose CT: head-to-head comparison with multidetector CT angiography
AU - Gutte, Henrik
AU - Mortensen, Jann
AU - Jensen, Claus Verner
AU - Johnbeck, Camilla Bardram
AU - von der Recke, Peter
AU - Petersen, Claus Leth
AU - Kjaergaard, Jesper
AU - Kristoffersen, Ulrik Sloth
AU - Kjaer, Andreas
N1 - Keywords: Aged; Female; Humans; Male; Middle Aged; Perfusion Imaging; Pulmonary Artery; Pulmonary Embolism; Pulmonary Ventilation; Radiation Dosage; Sensitivity and Specificity; Time Factors; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed
PY - 2009
Y1 - 2009
N2 - The diagnosis of pulmonary embolism (PE) is usually established by a combination of clinical assessment, D-dimer testing, and imaging with either pulmonary ventilation-perfusion (V/Q) scintigraphy or pulmonary multidetector CT (MDCT) angiography. Both V/Q SPECT and MDCT angiography seem to have high diagnostic accuracy. However, only limited data directly comparing these 2 modalities are available. Hybrid gamma-camera/MDCT systems have been introduced and allow simultaneous 3-dimensional lung V/Q SPECT and MDCT angiography, suitable for diagnosing PE. The aim of our study was to compare, in a prospective design, the diagnostic ability of V/Q SPECT, V/Q SPECT combined with low-dose CT, and pulmonary MDCT angiography obtained simultaneously using a combined SPECT/MDCT scanner in patients suspected of having PE. METHODS: Consecutive patients from June 2006 to February 2008 suspected of having acute PE were referred to the Department of Nuclear Medicine at Rigshospitalet or Frederiksberg Hospital, Denmark, for V/Q SPECT as a first-line imaging procedure. The number of eligible patients was 196. Patients with positive D-dimer results (>0.5 mmol/mL) or a clinical assessment with a Wells score greater than 2 were included and underwent V/Q SPECT, low-dose CT, and pulmonary MDCT angiography in a single session. Patient follow-up was 6 mo. RESULTS: A total of 81 simultaneous studies were available for analysis, of which 38% were from patients with PE. V/Q SPECT had a sensitivity of 97% and a specificity of 88%. When low-dose CT was added, the sensitivity was still 97% and the specificity increased to 100%. Perfusion SPECT with low-dose CT had a sensitivity of 93% and a specificity of 51%. MDCT angiography alone had a sensitivity of 68% and a specificity of 100%. CONCLUSION: We conclude that V/Q SPECT in combination with low-dose CT without contrast enhancement has an excellent diagnostic performance and should therefore probably be considered first-line imaging in the work-up of PE in most cases.
AB - The diagnosis of pulmonary embolism (PE) is usually established by a combination of clinical assessment, D-dimer testing, and imaging with either pulmonary ventilation-perfusion (V/Q) scintigraphy or pulmonary multidetector CT (MDCT) angiography. Both V/Q SPECT and MDCT angiography seem to have high diagnostic accuracy. However, only limited data directly comparing these 2 modalities are available. Hybrid gamma-camera/MDCT systems have been introduced and allow simultaneous 3-dimensional lung V/Q SPECT and MDCT angiography, suitable for diagnosing PE. The aim of our study was to compare, in a prospective design, the diagnostic ability of V/Q SPECT, V/Q SPECT combined with low-dose CT, and pulmonary MDCT angiography obtained simultaneously using a combined SPECT/MDCT scanner in patients suspected of having PE. METHODS: Consecutive patients from June 2006 to February 2008 suspected of having acute PE were referred to the Department of Nuclear Medicine at Rigshospitalet or Frederiksberg Hospital, Denmark, for V/Q SPECT as a first-line imaging procedure. The number of eligible patients was 196. Patients with positive D-dimer results (>0.5 mmol/mL) or a clinical assessment with a Wells score greater than 2 were included and underwent V/Q SPECT, low-dose CT, and pulmonary MDCT angiography in a single session. Patient follow-up was 6 mo. RESULTS: A total of 81 simultaneous studies were available for analysis, of which 38% were from patients with PE. V/Q SPECT had a sensitivity of 97% and a specificity of 88%. When low-dose CT was added, the sensitivity was still 97% and the specificity increased to 100%. Perfusion SPECT with low-dose CT had a sensitivity of 93% and a specificity of 51%. MDCT angiography alone had a sensitivity of 68% and a specificity of 100%. CONCLUSION: We conclude that V/Q SPECT in combination with low-dose CT without contrast enhancement has an excellent diagnostic performance and should therefore probably be considered first-line imaging in the work-up of PE in most cases.
U2 - 10.2967/jnumed.108.061606
DO - 10.2967/jnumed.108.061606
M3 - Journal article
C2 - 19910421
VL - 50
SP - 1987
EP - 1992
JO - The Journal of Nuclear Medicine
JF - The Journal of Nuclear Medicine
SN - 0161-5505
IS - 12
ER -