TY - JOUR
T1 - Determining minimal important change for the thyroid-related quality of life questionnaire thyPRO
AU - Nordqvist, Selma Flora
AU - Boesen, Victor Brun
AU - Rasmussen, Åse Krogh
AU - Feldt-Rasmussen, Ulla
AU - Hegedüs, Laszlo
AU - Bonnema, Steen Joop
AU - Cramon, Per Karkov
AU - Watt, Torquil
AU - Groenvold, Mogens
AU - Bjorner, Jakob Bue
PY - 2021
Y1 - 2021
N2 - Objective: ThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained. The purpose of this study was to determine values for minimal important change (MIC) for ThyPRO. Methods: A total of 435 patients treated for benign thyroid diseases completed ThyPRO at baseline and 6 weeks following treatment initiation. At 6 weeks follow-up, patients also completed Global Rating of Change items. For each 0–100 scale, two MIC values were identified: An MIC for groups, using the receiver operating characteristic (ROC) curve method and an MIC for individual patients, using the Reliable Change Index. Results: ROC analyses provided group-MIC estimates of 6.3–14.3 (score range 0–100). Evaluation of area under the curve (AUC) supported the robustness for 9 of 14 scales (AUC > 0.7). Reliable Change Index estimates of individual-MIC were 8.0–21.1. For all scales but two, the individual-MIC values were larger than the group-MIC values. Conclusions: Interpretability of ThyPRO was improved by the establishment of MIC values, which was 6.3–14.3 for groups and 8.0–21.1 for individuals. Thus, estimates of which changes are clinically relevant, are now available for future studies. We recommend using MIC values found by ROC analyses to evaluate changes in groups of patients, whereas MIC values identified by a dual criterion, including the reliability of changes, should be used for individual patients, for example, to identify individual responders in clinical studies or practice.
AB - Objective: ThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained. The purpose of this study was to determine values for minimal important change (MIC) for ThyPRO. Methods: A total of 435 patients treated for benign thyroid diseases completed ThyPRO at baseline and 6 weeks following treatment initiation. At 6 weeks follow-up, patients also completed Global Rating of Change items. For each 0–100 scale, two MIC values were identified: An MIC for groups, using the receiver operating characteristic (ROC) curve method and an MIC for individual patients, using the Reliable Change Index. Results: ROC analyses provided group-MIC estimates of 6.3–14.3 (score range 0–100). Evaluation of area under the curve (AUC) supported the robustness for 9 of 14 scales (AUC > 0.7). Reliable Change Index estimates of individual-MIC were 8.0–21.1. For all scales but two, the individual-MIC values were larger than the group-MIC values. Conclusions: Interpretability of ThyPRO was improved by the establishment of MIC values, which was 6.3–14.3 for groups and 8.0–21.1 for individuals. Thus, estimates of which changes are clinically relevant, are now available for future studies. We recommend using MIC values found by ROC analyses to evaluate changes in groups of patients, whereas MIC values identified by a dual criterion, including the reliability of changes, should be used for individual patients, for example, to identify individual responders in clinical studies or practice.
KW - Interpretability
KW - Minimal important change
KW - Patient-reported outcomes
KW - ThyPRO
KW - Thyroid-related quality of life
U2 - 10.1530/EC-21-0026
DO - 10.1530/EC-21-0026
M3 - Journal article
C2 - 33617467
AN - SCOPUS:85104175950
VL - 10
SP - 316
EP - 324
JO - Endocrine Connections
JF - Endocrine Connections
SN - 2049-3614
IS - 3
ER -