Development of a one-step probe based molecular assay for rapid immunodiagnosis of infection with M. Tuberculosisusing dried blood spots

Thomas Blauenfeldt; Jan Heyckendorf; Sidse Graff Jensen; Christoph Lange; Camilla Drabe; Thomas S. Hermansen; Lena De Thurah; Troels Lillebaek; Jesper Eugen-Olsen; Niels Seersholm; Søren Hoff; Jesper Bonde; Morten Ruhwald

doi:10.1371/journal.pone.0105628

Development of a one-step probe based molecular assay for rapid immunodiagnosis of infection with M. Tuberculosisusing dried blood spots

Thomas Blauenfeldt, Jan Heyckendorf, Sidse Graff Jensen, Christoph Lange, Camilla Drabe, Thomas S. Hermansen, Lena De Thurah, Troels Lillebaek, Jesper Eugen-Olsen, Niels Seersholm, Søren Hoff, Jesper Bonde, Morten Ruhwald

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

22 Citationer (Scopus)

6 Downloads (Pure)

Abstract

Background: Antigen specific release of IP-10 is the most promising alternative marker to IFN-γ for infection with M. tuberculosis. Compared to Interferon-γ release assays (IGRA), IP-10 is released in high levels enabling novel approaches such as field friendly dried blood spots (DBS) and molecular detection.

Originalsprog	Engelsk
Artikelnummer	e105628
Tidsskrift	PLoS ONE
Vol/bind	9
Udgave nummer	9
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0105628
Status	Udgivet - 3 sep. 2014
Udgivet eksternt	Ja

Adgang til dokumentet

10.1371/journal.pone.0105628Licens: CC BY

Development of a one-step probe based molecular assay for rapid immunodiagnosis of infection with M. Tuberculosisusing dried blood spotsForlagets udgivne version, 542 KBLicens: CC BY

Citationsformater

Blauenfeldt, T., Heyckendorf, J., Jensen, S. G., Lange, C., Drabe, C., Hermansen, T. S., De Thurah, L., Lillebaek, T., Eugen-Olsen, J., Seersholm, N., Hoff, S., Bonde, J., & Ruhwald, M. (2014). Development of a one-step probe based molecular assay for rapid immunodiagnosis of infection with M. Tuberculosisusing dried blood spots. PLoS ONE, 9(9), Artikel e105628. https://doi.org/10.1371/journal.pone.0105628

Blauenfeldt, T, Heyckendorf, J, Jensen, SG, Lange, C, Drabe, C, Hermansen, TS, De Thurah, L, Lillebaek, T, Eugen-Olsen, J, Seersholm, N, Hoff, S, Bonde, J & Ruhwald, M 2014, 'Development of a one-step probe based molecular assay for rapid immunodiagnosis of infection with M. Tuberculosisusing dried blood spots', PLoS ONE, bind 9, nr. 9, e105628. https://doi.org/10.1371/journal.pone.0105628

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AU - Lange, Christoph

AU - Drabe, Camilla

AU - Hermansen, Thomas S.

AU - De Thurah, Lena

AU - Lillebaek, Troels

AU - Eugen-Olsen, Jesper

AU - Seersholm, Niels

AU - Hoff, Søren

AU - Bonde, Jesper

AU - Ruhwald, Morten

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AB - Background: Antigen specific release of IP-10 is the most promising alternative marker to IFN-γ for infection with M. tuberculosis. Compared to Interferon-γ release assays (IGRA), IP-10 is released in high levels enabling novel approaches such as field friendly dried blood spots (DBS) and molecular detection.

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