Diagnosing Acute Graft-Versus-Host Disease in Children Undergoing Hematopoietic Stem Cell Transplantation — Comparison of the Modified Glucksberg Criteria Versus the MAGIC Criteria

Sarah Weischendorff*, Nakisa Kamari-Kany, Katrine Kielsen, Marianne Ifversen, Klaus Müller

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftLetterForskningpeer review

Abstract

Diagnosing acute graft-versus-host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) is challenging due to heterogeneity in interpreting current clinical criteria. Recently, the Mount Sinai Acute GvHD International Consortium (MAGIC) criteria were introduced to improve diagnostic consistency. In a study of 117 pediatric patients undergoing HSCT, the modified Glucksberg and the MAGIC criteria were retrospectively compared. The MAGIC criteria identified significantly more cases of gastrointestinal (GI) aGvHD and increased overall severity, important for guiding systemic treatment. Diagnosing upper GI aGvHD based solely on symptomatology (MAGIC) proved difficult, suggesting a need for stricter definitions. For lower GI aGvHD, the modifications were clearly beneficial, although diarrhea duration remains unspecified.

OriginalsprogEngelsk
Artikelnummere31502
BogseriePediatric Blood and Cancer
Vol/bind72
Udgave nummer3
Antal sider4
ISSN1545-5009
DOI
StatusUdgivet - 2025

Bibliografisk note

Publisher Copyright:
© 2025 The Author(s). Pediatric Blood & Cancer published by Wiley Periodicals LLC.

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