Abstract
Objective: Differentiating between the central hypersomnias presents a challenge to the diagnosis of patients with hypersomnolence. Actitigraphy may support efforts to distinguish them. We aimed to evaluate: 1) the ability of actigraphy to quantify sleep continuity measures in comparison with polysomnography in patients with hypersomnolence; 2) whether actigraphy can distinguish patients with hypersomnolence with normal hypocretin-1 in cerebrospinal fluid from patients with narcolepsy type 1 and from sleep-healthy controls; and 3) the distinct activity profiles and circadian rhythms of patients with narcolepsy type 1, patients with hypersomnolence with normal hypocretin-1 in cerebrospinal fluid, and sleep-healthy controls. Method: Polysomnography, multiple sleep latency tests and actigraphy were conducted in 14 patients with narcolepsy type 1, 29 patients with hypersomnolence with normal hypocretin-1 in cerebrospinal fluid and 15 sleep-healthy controls. Results: Actigraphy quantified several sleep continuity measures consistently with polysomnography in all the patients. Actigraphy distinguished patients with hypersomnolence with normal hypocretin-1 in cerebrospinal fluid from patients with narcolepsy type 1 and sleep-healthy controls. Patients with narcolepsy type 1 had poor sleep quality and altered circadian rest-activity rhythm compared with controls. Conclusion: Actigraphy is an adequate tool for establishing the amount of night sleep and supports the differential diagnosis of patients with hypersomnolence.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Sleep Medicine |
| Vol/bind | 85 |
| Sider (fra-til) | 1-7 |
| Antal sider | 7 |
| ISSN | 1389-9457 |
| DOI | |
| Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:We are indebted to all the patients who participated in this study, without whose contributions it would not have been possible. We thank the polysomnography technicians, who performed the electrophysiological examinations; our department secretaries, for helping with the patients and administrative work; Michael Ipsen, who contributed to the statistical analysis; and Phil Mason, for language editing.
Publisher Copyright:
© 2021 Elsevier B.V.
Finansiering
We are indebted to all the patients who participated in this study, without whose contributions it would not have been possible. We thank the polysomnography technicians, who performed the electrophysiological examinations; our department secretaries, for helping with the patients and administrative work; Michael Ipsen, who contributed to the statistical analysis; and Phil Mason, for language editing.
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