@article{e07d84e0a0da11dd86a6000ea68e967b,
title = "Dichotomy in the human CD4+ T-cell response to Leishmania parasites",
abstract = "Leishmania parasites cause human diseases ranging from self-healing cutaneous ulcers to fatal systemic infections. In addition, many individuals become infected without developing disease. In mice the two subsets of CD4+ T cells, Th1 and Th2, have different effects on the outcome of experimental Leishmania infections. Th1 cells producing interferon-gamma (IFN-gamma) mediate resistance, whereas Th2 cells producing interleukin-4 (IL-4) and IL-10 are associated with susceptibility and exacerbation. Evidence is accumulating that a Th1/Th2 dichotomy in the T-cell response to Leishmania exists also in humans, and that the balance between subsets of parasite-specific T cells may play an important regulatory role in determining the outcome of the infections.",
author = "M Kemp and Kurtzhals, {J A} and A Kharazmi and Theander, {T G}",
note = "Keywords: Animals; Antigens, CD; Antigens, CD4; CD4-Positive T-Lymphocytes; Humans; Immunity, Cellular; Interferon Type II; Leishmania; Leishmaniasis; Mice",
year = "1994",
language = "English",
volume = "102",
pages = "81--8",
journal = "Acta Pathologica Microbiologica et Immunologica Scandinavica",
issn = "0903-4641",
publisher = "Wiley Online",
number = "2",
}