Differential developmental expression of transcription factors GATA-4 and GATA-6, their cofactor FOG-2 and downstream target genes in testicular carcinoma in situ and germ cell tumors

Jonna Salonen; E Rajpert-De Meyts; Susanna Mannisto; John E Nielsen; Niels Graem; Jorma Toppari; Markku Heikinheimo

doi:http://dx.doi.org/10.1530/EJE-09-0734

Differential developmental expression of transcription factors GATA-4 and GATA-6, their cofactor FOG-2 and downstream target genes in testicular carcinoma in situ and germ cell tumors

Jonna Salonen, E Rajpert-De Meyts, Susanna Mannisto, John E Nielsen, Niels Graem, Jorma Toppari, Markku Heikinheimo

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

16 Citationer (Scopus)

Abstract

Testicular germ cell cancer is the most common malignancy among young males. The pre-invasive precursor, carcinoma in situ testis (CIS), presumably originates from arrested and transformed fetal gonocytes. Given that GATA transcription factors have essential roles in embryonic and testicular development, we explored the expression of GATA-4, GATA-6, cofactor friend of GATA (FOG)-2, and downstream target genes during human testis development and addressed the question whether changes in this pathway may contribute to germ cell neoplasms.

Originalsprog	Engelsk
Tidsskrift	European Journal of Endocrinology
Vol/bind	162
Udgave nummer	3
Sider (fra-til)	625-31
Antal sider	7
ISSN	0804-4643
DOI	https://doi.org/10.1530/EJE-09-0734
Status	Udgivet - 1 mar. 2010

Adgang til dokumentet

http://dx.doi.org/10.1530/EJE-09-0734

Citationsformater

Salonen, J., Rajpert-De Meyts, E., Mannisto, S., Nielsen, J. E., Graem, N., Toppari, J., & Heikinheimo, M. (2010). Differential developmental expression of transcription factors GATA-4 and GATA-6, their cofactor FOG-2 and downstream target genes in testicular carcinoma in situ and germ cell tumors. European Journal of Endocrinology, 162(3), 625-31. https://doi.org/10.1530/EJE-09-0734

Differential developmental expression of transcription factors GATA-4 and GATA-6, their cofactor FOG-2 and downstream target genes in testicular carcinoma in situ and germ cell tumors. / Salonen, Jonna; Rajpert-De Meyts, E; Mannisto, Susanna; Nielsen, John E; Graem, Niels; Toppari, Jorma; Heikinheimo, Markku.

I: European Journal of Endocrinology, Bind 162, Nr. 3, 01.03.2010, s. 625-31.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Salonen, J, Rajpert-De Meyts, E, Mannisto, S, Nielsen, JE, Graem, N, Toppari, J & Heikinheimo, M 2010, 'Differential developmental expression of transcription factors GATA-4 and GATA-6, their cofactor FOG-2 and downstream target genes in testicular carcinoma in situ and germ cell tumors', European Journal of Endocrinology, bind 162, nr. 3, s. 625-31. https://doi.org/10.1530/EJE-09-0734

Salonen, Jonna ; Rajpert-De Meyts, E ; Mannisto, Susanna ; Nielsen, John E ; Graem, Niels ; Toppari, Jorma ; Heikinheimo, Markku. / Differential developmental expression of transcription factors GATA-4 and GATA-6, their cofactor FOG-2 and downstream target genes in testicular carcinoma in situ and germ cell tumors. I: European Journal of Endocrinology. 2010 ; Bind 162, Nr. 3. s. 625-31.

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