Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA

Vera V Pinto; Sisse B Ditlev; Kamilla E Jensen; Mafalda Resende; Madeleine Dahlbäck; Gorm Andersen; Pernille Andersen; Thor G Theander; Ali Salanti; Morten A Nielsen

doi:10.1371/journal.pone.0017942

Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA

Vera V Pinto, Sisse B Ditlev, Kamilla E Jensen, Mafalda Resende, Madeleine Dahlbäck, Gorm Andersen, Pernille Andersen, Thor G Theander, Ali Salanti, Morten A Nielsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

14 Citationer (Scopus)

Abstract

In Plasmodium falciparum malaria endemic areas placental malaria (PM) is an important complication of malaria. The recurrence of malaria in primigravidae women irrespective of acquired protection during childhood is caused by the interaction between the parasite-expressed VAR2CSA antigen and chondroitin sulfate A (CSA) in the placental intervillous space and lack of protective antibodies. PM impairs fetal development mainly by excessive inflammation processes. After infections during pregnancy women acquire immunity to PM conferred by antibodies against VAR2CSA. Ideally, a vaccine against PM will induce antibody-mediated immune responses that block the adhesion of infected erythrocytes (IE) in the placenta.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	6
Udgave nummer	3
Sider (fra-til)	e17942
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0017942
Status	Udgivet - 1 jan. 2011

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10.1371/journal.pone.0017942

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title = "Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA",

abstract = "In Plasmodium falciparum malaria endemic areas placental malaria (PM) is an important complication of malaria. The recurrence of malaria in primigravidae women irrespective of acquired protection during childhood is caused by the interaction between the parasite-expressed VAR2CSA antigen and chondroitin sulfate A (CSA) in the placental intervillous space and lack of protective antibodies. PM impairs fetal development mainly by excessive inflammation processes. After infections during pregnancy women acquire immunity to PM conferred by antibodies against VAR2CSA. Ideally, a vaccine against PM will induce antibody-mediated immune responses that block the adhesion of infected erythrocytes (IE) in the placenta.",

keywords = "Animals, Antibodies, Protozoan, Antibody Formation, Antigens, Protozoan, Enzyme-Linked Immunosorbent Assay, Epitopes, Erythrocytes, Female, Humans, Immunoglobulin G, Malaria Vaccines, Malaria, Falciparum, Mice, Placenta, Plasmodium falciparum, Pregnancy, Protein Array Analysis, Protein Structure, Tertiary, Rabbits, Rats, Recombinant Proteins, Species Specificity",

author = "Pinto, {Vera V} and Ditlev, {Sisse B} and Jensen, {Kamilla E} and Mafalda Resende and Madeleine Dahlb{\"a}ck and Gorm Andersen and Pernille Andersen and Theander, {Thor G} and Ali Salanti and Nielsen, {Morten A}",

year = "2011",

month = jan,

day = "1",

doi = "10.1371/journal.pone.0017942",

language = "English",

volume = "6",

pages = "e17942",

journal = "P L o S One",

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TY - JOUR

T1 - Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA

AU - Pinto, Vera V

AU - Ditlev, Sisse B

AU - Jensen, Kamilla E

AU - Resende, Mafalda

AU - Dahlbäck, Madeleine

AU - Andersen, Gorm

AU - Andersen, Pernille

AU - Theander, Thor G

AU - Salanti, Ali

AU - Nielsen, Morten A

PY - 2011/1/1

Y1 - 2011/1/1

N2 - In Plasmodium falciparum malaria endemic areas placental malaria (PM) is an important complication of malaria. The recurrence of malaria in primigravidae women irrespective of acquired protection during childhood is caused by the interaction between the parasite-expressed VAR2CSA antigen and chondroitin sulfate A (CSA) in the placental intervillous space and lack of protective antibodies. PM impairs fetal development mainly by excessive inflammation processes. After infections during pregnancy women acquire immunity to PM conferred by antibodies against VAR2CSA. Ideally, a vaccine against PM will induce antibody-mediated immune responses that block the adhesion of infected erythrocytes (IE) in the placenta.

AB - In Plasmodium falciparum malaria endemic areas placental malaria (PM) is an important complication of malaria. The recurrence of malaria in primigravidae women irrespective of acquired protection during childhood is caused by the interaction between the parasite-expressed VAR2CSA antigen and chondroitin sulfate A (CSA) in the placental intervillous space and lack of protective antibodies. PM impairs fetal development mainly by excessive inflammation processes. After infections during pregnancy women acquire immunity to PM conferred by antibodies against VAR2CSA. Ideally, a vaccine against PM will induce antibody-mediated immune responses that block the adhesion of infected erythrocytes (IE) in the placenta.

KW - Animals

KW - Antibodies, Protozoan

KW - Antibody Formation

KW - Antigens, Protozoan

KW - Enzyme-Linked Immunosorbent Assay

KW - Epitopes

KW - Erythrocytes

KW - Female

KW - Humans

KW - Immunoglobulin G

KW - Malaria Vaccines

KW - Malaria, Falciparum

KW - Mice

KW - Placenta

KW - Plasmodium falciparum

KW - Pregnancy

KW - Protein Array Analysis

KW - Protein Structure, Tertiary

KW - Rabbits

KW - Rats

KW - Recombinant Proteins

KW - Species Specificity

U2 - 10.1371/journal.pone.0017942

DO - 10.1371/journal.pone.0017942

M3 - Journal article

C2 - 21464946

SN - 1932-6203

VL - 6

SP - e17942

JO - P L o S One

JF - P L o S One

IS - 3

ER -