Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum

D R Cavanagh; C Dobaño; I M Elhassan; K Marsh; A Elhassan; L Hviid; E A Khalil; T G Theander; D E Arnot; J S McBride

doi:10.1128/IAI.69.2.1207-1211.2001

Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum

D R Cavanagh, C Dobaño, I M Elhassan, K Marsh, A Elhassan, L Hviid, E A Khalil, T G Theander, D E Arnot, J S McBride

Centre for Medical Parasitology

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

60 Citationer (Scopus)

Abstract

Udgivelsesdato: 2001-Feb

Originalsprog	Engelsk
Tidsskrift	Infection and Immunity
Vol/bind	69
Udgave nummer	2
Sider (fra-til)	1207-11
Antal sider	4
ISSN	0019-9567
DOI	https://doi.org/10.1128/IAI.69.2.1207-1211.2001
Status	Udgivet - 2001

Bibliografisk note

Keywords: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Child; Child, Preschool; Humans; Immunoglobulin G; Infant; Merozoite Surface Protein 1; Middle Aged; Peptide Fragments; Plasmodium falciparum

Adgang til dokumentet

10.1128/IAI.69.2.1207-1211.2001

Citationsformater

Cavanagh, D. R., Dobaño, C., Elhassan, I. M., Marsh, K., Elhassan, A., Hviid, L., Khalil, E. A., Theander, T. G., Arnot, D. E., & McBride, J. S. (2001). Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum. Infection and Immunity, 69(2), 1207-11. https://doi.org/10.1128/IAI.69.2.1207-1211.2001

Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum. / Cavanagh, D R; Dobaño, C; Elhassan, I M; Marsh, K; Elhassan, A; Hviid, L; Khalil, E A; Theander, T G; Arnot, D E; McBride, J S.

I: Infection and Immunity, Bind 69, Nr. 2, 2001, s. 1207-11.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Cavanagh, DR, Dobaño, C, Elhassan, IM, Marsh, K, Elhassan, A, Hviid, L, Khalil, EA, Theander, TG, Arnot, DE & McBride, JS 2001, 'Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum', Infection and Immunity, bind 69, nr. 2, s. 1207-11. https://doi.org/10.1128/IAI.69.2.1207-1211.2001

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title = "Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum",

abstract = "Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.",

author = "Cavanagh, {D R} and C Doba{\~n}o and Elhassan, {I M} and K Marsh and A Elhassan and L Hviid and Khalil, {E A} and Theander, {T G} and Arnot, {D E} and McBride, {J S}",

note = "Keywords: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Child; Child, Preschool; Humans; Immunoglobulin G; Infant; Merozoite Surface Protein 1; Middle Aged; Peptide Fragments; Plasmodium falciparum",

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doi = "10.1128/IAI.69.2.1207-1211.2001",

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T1 - Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum

AU - Cavanagh, D R

AU - Dobaño, C

AU - Elhassan, I M

AU - Marsh, K

AU - Elhassan, A

AU - Hviid, L

AU - Khalil, E A

AU - Theander, T G

AU - Arnot, D E

AU - McBride, J S

N1 - Keywords: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Child; Child, Preschool; Humans; Immunoglobulin G; Infant; Merozoite Surface Protein 1; Middle Aged; Peptide Fragments; Plasmodium falciparum

PY - 2001

Y1 - 2001

N2 - Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.

AB - Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.

U2 - 10.1128/IAI.69.2.1207-1211.2001

DO - 10.1128/IAI.69.2.1207-1211.2001

M3 - Journal article

C2 - 11160024

VL - 69

SP - 1207

EP - 1211

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 2

ER -