Abstract
Originalsprog | Engelsk |
---|---|
Tidsskrift | Brain |
Vol/bind | 131 |
Udgave nummer | 2 |
Sider (fra-til) | 559-72 |
Antal sider | 13 |
ISSN | 0006-8950 |
DOI | |
Status | Udgivet - 2008 |
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Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: a longitudinal study. / Sidaros, Annette ; Engberg, A.W.; Sidaros, Karam Michel Messiha; Liptrot, Matthew George; Herning, M.; Petersen, Palle; Paulson, Olaf B.; Jernigan, Terry Lynne; Rostrup, E.
I: Brain, Bind 131, Nr. 2, 2008, s. 559-72.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: a longitudinal study
AU - Sidaros, Annette
AU - Engberg, A.W.
AU - Sidaros, Karam Michel Messiha
AU - Liptrot, Matthew George
AU - Herning, M.
AU - Petersen, Palle
AU - Paulson, Olaf B.
AU - Jernigan, Terry Lynne
AU - Rostrup, E.
PY - 2008
Y1 - 2008
N2 - Diffusion tensor imaging (DTI) has been proposed as a sensitive biomarker of traumatic white matter injury, which could potentially serve as a tool for prognostic assessment and for studying microstructural changes during recovery from traumatic brain injury (TBI). However, there is a lack of longitudinal studies on TBI that follow DTI changes over time and correlate findings with long-term clinical outcome. We performed a prospective longitudinal study of 30 adult patients admitted for subacute rehabilitation following severe traumatic brain injury. DTI and conventional MRI were acquired at mean 8 weeks (5-11 weeks), and repeated in 23 of the patients at mean 12 months (9-15 months) post-trauma. Using a region-of-interest-based approach, DTI parameters were compared to those of healthy matched controls, scanned during the same time period and rescanned with a similar interval as that of patients. At the initial scan, fractional anisotropy was reduced in all the investigated white matter regions in patients compared to controls (P
AB - Diffusion tensor imaging (DTI) has been proposed as a sensitive biomarker of traumatic white matter injury, which could potentially serve as a tool for prognostic assessment and for studying microstructural changes during recovery from traumatic brain injury (TBI). However, there is a lack of longitudinal studies on TBI that follow DTI changes over time and correlate findings with long-term clinical outcome. We performed a prospective longitudinal study of 30 adult patients admitted for subacute rehabilitation following severe traumatic brain injury. DTI and conventional MRI were acquired at mean 8 weeks (5-11 weeks), and repeated in 23 of the patients at mean 12 months (9-15 months) post-trauma. Using a region-of-interest-based approach, DTI parameters were compared to those of healthy matched controls, scanned during the same time period and rescanned with a similar interval as that of patients. At the initial scan, fractional anisotropy was reduced in all the investigated white matter regions in patients compared to controls (P
KW - Adolescent
KW - Adult
KW - Aged
KW - Anisotropy
KW - Brain Injuries
KW - Brain Injury, Chronic
KW - Brain Mapping
KW - Corpus Callosum
KW - Diffusion Magnetic Resonance Imaging
KW - Female
KW - Glasgow Outcome Scale
KW - Humans
KW - Longitudinal Studies
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Neuronal Plasticity
KW - Prognosis
KW - Prospective Studies
KW - Tegmentum Mesencephali
U2 - 10.1093/brain/awm294
DO - 10.1093/brain/awm294
M3 - Journal article
C2 - 18083753
VL - 131
SP - 559
EP - 572
JO - Brain
JF - Brain
SN - 0006-8950
IS - 2
ER -