Disseminated Mycobacterium avium complex infection in a woman with anti-interferon-gamma autoantibodies

Victor Naestholt Dahl; Bibi Uhre Nielsen; Christian Morberg Wejse; Hanne Vibeke Marquart; Jakob Thaning Bay; Jakob Hjorth von Stemann; Troels Lillebæk; Aase Bengaard Andersen

doi:10.1016/j.idcr.2021.e01300

Disseminated Mycobacterium avium complex infection in a woman with anti-interferon-gamma autoantibodies

Victor Naestholt Dahl, Bibi Uhre Nielsen, Christian Morberg Wejse, Hanne Vibeke Marquart, Jakob Thaning Bay, Jakob Hjorth von Stemann, Troels Lillebæk, Aase Bengaard Andersen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

1 Citationer (Scopus)

18 Downloads (Pure)

Abstract

Defects in the interleukin-12/interferon-gamma (IFN-γ) pathway and anti-IFN-γ antibodies have been associated with severe nontuberculous mycobacteria (NTM) infections. Consequently, disseminated NTM infections should prompt investigations for immunodeficiency. Herein, we report a case of a treatment refractory and ultimately disseminated and fatal Mycobacterium avium complex infection in a 71-year-old woman of Thai origin. Simultaneously, she had recurrent Salmonella kentucky cultured from stool samples and chronic perianal HSV-2 lesions. Late in the course of disease, anti–IFN-γ autoantibodies were demonstrated. Clinical studies investigating immunomodulating therapy and treatment among patients with anti-IFN-γ autoantibodies are lacking and, in this case, treatment seemed of a more palliative nature.

Originalsprog	Engelsk
Artikelnummer	e01300
Tidsskrift	IDCases
Vol/bind	26
ISSN	2214-2509
DOI	https://doi.org/10.1016/j.idcr.2021.e01300
Status	Udgivet - 2021

Adgang til dokumentet

10.1016/j.idcr.2021.e01300Licens: CC BY

FulltextForlagets udgivne version, 1,22 MBLicens: CC BY

Citationsformater

Disseminated Mycobacterium avium complex infection in a woman with anti-interferon-gamma autoantibodies. / Dahl, Victor Naestholt; Nielsen, Bibi Uhre; Wejse, Christian Morberg; Marquart, Hanne Vibeke ; Bay, Jakob Thaning; von Stemann, Jakob Hjorth; Lillebæk, Troels; Andersen, Aase Bengaard.

I: IDCases, Bind 26, e01300, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Disseminated Mycobacterium avium complex infection in a woman with anti-interferon-gamma autoantibodies",

abstract = "Defects in the interleukin-12/interferon-gamma (IFN-γ) pathway and anti-IFN-γ antibodies have been associated with severe nontuberculous mycobacteria (NTM) infections. Consequently, disseminated NTM infections should prompt investigations for immunodeficiency. Herein, we report a case of a treatment refractory and ultimately disseminated and fatal Mycobacterium avium complex infection in a 71-year-old woman of Thai origin. Simultaneously, she had recurrent Salmonella kentucky cultured from stool samples and chronic perianal HSV-2 lesions. Late in the course of disease, anti–IFN-γ autoantibodies were demonstrated. Clinical studies investigating immunomodulating therapy and treatment among patients with anti-IFN-γ autoantibodies are lacking and, in this case, treatment seemed of a more palliative nature.",

keywords = "Nontuberculous mycobacteria, Mycobacterium avium complex, Immunodeficiency, Anti-IFN-gamma autoantibodies",

author = "Dahl, {Victor Naestholt} and Nielsen, {Bibi Uhre} and Wejse, {Christian Morberg} and Marquart, {Hanne Vibeke} and Bay, {Jakob Thaning} and {von Stemann}, {Jakob Hjorth} and Troels Lilleb{\ae}k and Andersen, {Aase Bengaard}",

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T1 - Disseminated Mycobacterium avium complex infection in a woman with anti-interferon-gamma autoantibodies

AU - Dahl, Victor Naestholt

AU - Nielsen, Bibi Uhre

AU - Wejse, Christian Morberg

AU - Marquart, Hanne Vibeke

AU - Bay, Jakob Thaning

AU - von Stemann, Jakob Hjorth

AU - Lillebæk, Troels

AU - Andersen, Aase Bengaard

PY - 2021

Y1 - 2021

N2 - Defects in the interleukin-12/interferon-gamma (IFN-γ) pathway and anti-IFN-γ antibodies have been associated with severe nontuberculous mycobacteria (NTM) infections. Consequently, disseminated NTM infections should prompt investigations for immunodeficiency. Herein, we report a case of a treatment refractory and ultimately disseminated and fatal Mycobacterium avium complex infection in a 71-year-old woman of Thai origin. Simultaneously, she had recurrent Salmonella kentucky cultured from stool samples and chronic perianal HSV-2 lesions. Late in the course of disease, anti–IFN-γ autoantibodies were demonstrated. Clinical studies investigating immunomodulating therapy and treatment among patients with anti-IFN-γ autoantibodies are lacking and, in this case, treatment seemed of a more palliative nature.

AB - Defects in the interleukin-12/interferon-gamma (IFN-γ) pathway and anti-IFN-γ antibodies have been associated with severe nontuberculous mycobacteria (NTM) infections. Consequently, disseminated NTM infections should prompt investigations for immunodeficiency. Herein, we report a case of a treatment refractory and ultimately disseminated and fatal Mycobacterium avium complex infection in a 71-year-old woman of Thai origin. Simultaneously, she had recurrent Salmonella kentucky cultured from stool samples and chronic perianal HSV-2 lesions. Late in the course of disease, anti–IFN-γ autoantibodies were demonstrated. Clinical studies investigating immunomodulating therapy and treatment among patients with anti-IFN-γ autoantibodies are lacking and, in this case, treatment seemed of a more palliative nature.

KW - Nontuberculous mycobacteria

KW - Mycobacterium avium complex

KW - Immunodeficiency

KW - Anti-IFN-gamma autoantibodies

U2 - 10.1016/j.idcr.2021.e01300

DO - 10.1016/j.idcr.2021.e01300

M3 - Journal article

C2 - 34692415

VL - 26

JO - IDCases

JF - IDCases

SN - 2214-2509

M1 - e01300

ER -