Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006

Jenny J Zhang, Tharanga N Senaratne, Rachel Daniels, Clarissa Valim, Michael Alifrangis, Priyanie Amerasinghe, Flemming Konradsen, Rupika Rajakaruna, Dyann F Wirth, Nadira D Karunaweera

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3 Citationer (Scopus)

Abstract

Abstract. Widespread antimalarial resistance has been a barrier to malaria elimination efforts in Sri Lanka. Analysis of genetic markers in historic parasites may uncover trends in the spread of resistance. We examined the frequency of Plasmodium falciparum chloroquine transporter (pfcrt; codons 72-76) haplotypes in Sri Lanka in 1996-1998 and 2004-2006 using a high-resolution melting assay. Among 59 samples from 1996 to 1998, we detected the SVMNT (86%), CVMNK (10%), and CVIET (2%) haplotypes, with a positive trend in SVMNT and a negative trend in CVMNK frequency (P = 0.004) over time. Among 24 samples from 2004 to 2006, we observed only the SVMNT haplotype. This finding indicates selection for the SVMNT haplotype over time and its possible fixation in the population.
OriginalsprogEngelsk
TidsskriftAmerican Journal of Tropical Medicine and Hygiene
Vol/bind85
Udgave nummer5
Sider (fra-til)811-4
Antal sider4
ISSN0002-9637
DOI
StatusUdgivet - 1 nov. 2011

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