Diurnal and day-to-day variation of isometric muscle strength in myasthenia gravis

Lotte Vinge, Johannes Jakobsen, Asger Roer Pedersen, Henning Andersen

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10 Citationer (Scopus)

Abstract

INTRODUCTION: In patients with myasthenia gravis (MG), muscle strength is expected to decrease gradually during the day due to physical activities.

METHODS: Isometric muscle strength at the shoulder, knee, and ankle was determined in 10 MG patients (MGFA class II-IV) who were receiving usual medical treatment and in 10 control subjects. To determine diurnal and day-to-day variation, muscle strength was measured 4 times during day 1 and once at day 2.

RESULTS: Knee extension strength decreased during the day in both patients and controls. Neither diurnal nor day-to-day variation of muscle strength was higher in patients compared with controls.

CONCLUSIONS: Patients with mild to moderate MG did not have increased variation of isometric muscle strength during the day or from day-to-day compared with controls. This suggests that isometric muscle performance can be determined with high reproducibility in similar groups of MG patients without regard to time of day.

OriginalsprogEngelsk
TidsskriftMuscle & Nerve
Vol/bind53
Udgave nummer1
Sider (fra-til)67-72
Antal sider6
ISSN0148-639X
DOI
StatusUdgivet - jan. 2016
Udgivet eksterntJa

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