Does cerebral hypoxia facilitate central fatigue?

Central fatigue originates within the central nervous system and is characterized by a decreasein voluntary muscle activation. Reduced systemic O2availability can facilitate central fatigue byenhancing the afferent input of the chemosensitive nerves that play a pivotal role in developmentof central fatigue. There is accumulating evidence that, in some situations, inadequate O2availability to the brain itself promotes central fatigue. This short review presents some of therecent findings supporting a direct effect of inadequate cerebral O2availability on central fatigueand addresses the persisting limitations.