Drosophila as a Model to Study the Link between Metabolism and Cancer

Hector Herranz, Stephen M. Cohen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

21 Citationer (Scopus)
173 Downloads (Pure)

Abstract

Cellular metabolism has recently been recognized as a hallmark of cancer. Investigating the origin and effects of the reprogrammed metabolism of tumor cells, and identifying its genetic mediators, will improve our understanding of how these changes contribute to disease progression and may suggest new approaches to therapy. Drosophila melanogaster is emerging as a valuable model to study multiple aspects of tumor formation and malignant transformation. In this review, we discuss the use of Drosophila as model to study how changes in cellular metabolism, as well as metabolic disease, contribute to cancer.
OriginalsprogEngelsk
Artikelnummer15
TidsskriftJournal of Developmental Biology
Vol/bind5
Udgave nummer4
Antal sider14
DOI
StatusUdgivet - dec. 2017

Citationsformater