Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease.

Victor Matheu; Ove Bäck; Emma Mondoc; Shohreh Issazadeh-Navikas

Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease.

Victor Matheu, Ove Bäck, Emma Mondoc, Shohreh Issazadeh-Navikas

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

237 Citationer (Scopus)

Abstract

Udgivelsesdato: 2003-Sep

Originalsprog	Engelsk
Tidsskrift	Journal of Allergy and Clinical Immunology
Vol/bind	112
Udgave nummer	3
Sider (fra-til)	585-92
Antal sider	7
ISSN	0091-6749
Status	Udgivet - 2003

Bibliografisk note

Keywords: Allergens; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Eosinophilia; Female; Hypersensitivity; Hypersensitivity, Immediate; Immunoglobulin E; Immunoglobulin G; Interleukin-4; Lung; Mice; Mice, Knockout; Ovalbumin; Th1 Cells; Th2 Cells; Time Factors; Vitamin D

Citationsformater

Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. / Matheu, Victor; Bäck, Ove; Mondoc, Emma et al.
I: Journal of Allergy and Clinical Immunology, Bind 112, Nr. 3, 2003, s. 585-92.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

@article{30761c0057ca11dd8d9f000ea68e967b,

title = "Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease.",

abstract = "BACKGROUND: Vitamin D, a common food additive, has been shown to prevent the induction of experimental autoimmune diseases in mice. A possible immune deviation from T(H)1 to T(H)2 responses has been postulated. Although there is no doubt about the beneficial effects of vitamin D, its role in allergy has not been investigated. OBJECTIVE: To define the role of vitamin D in modulating the development of a T(H)2-mediated disease, we used a murine model of pulmonary eosinophilic inflammation. METHODS: Five-week-old mice were primed on day 0 with ovalbumin intraperitoneally. Then they were nasally challenged with ovalbumin on days 7, 8, 9, and 10, and on day 11, samples were studied. Some mice received subcutaneous injections of vitamin D every second day as follows: days -3, -1, 1, 3, 5, 7, and 9. The control groups received PBS on the same days. RESULTS: Early treatment with vitamin D augmented allergen-induced T-cell proliferation along with T(H)2 cytokine (IL-4 and IL-13) and IgE production. Surprisingly, the local inflammatory response in bronchoalveolar lavage fluid and lung tissue was significantly ameliorated with impaired recruitment of eosinophils and inferior levels of IL-5. These findings were attributed to late treatment with vitamin D after establishment of an early immune response. CONCLUSION: We suggest that excess supplementation of vitamin D could influence the development of a sustained T(H)2 response, leading to an increasing prevalence of allergy, whereas vitamin D might hold promising beneficial effects in airway eosinophilia.",

author = "Victor Matheu and Ove B{\"a}ck and Emma Mondoc and Shohreh Issazadeh-Navikas",

note = "Keywords: Allergens; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Eosinophilia; Female; Hypersensitivity; Hypersensitivity, Immediate; Immunoglobulin E; Immunoglobulin G; Interleukin-4; Lung; Mice; Mice, Knockout; Ovalbumin; Th1 Cells; Th2 Cells; Time Factors; Vitamin D",

year = "2003",

language = "English",

volume = "112",

pages = "585--92",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Mosby Inc.",

number = "3",

}

TY - JOUR

T1 - Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease.

AU - Matheu, Victor

AU - Bäck, Ove

AU - Mondoc, Emma

AU - Issazadeh-Navikas, Shohreh

N1 - Keywords: Allergens; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Eosinophilia; Female; Hypersensitivity; Hypersensitivity, Immediate; Immunoglobulin E; Immunoglobulin G; Interleukin-4; Lung; Mice; Mice, Knockout; Ovalbumin; Th1 Cells; Th2 Cells; Time Factors; Vitamin D

PY - 2003

Y1 - 2003

N2 - BACKGROUND: Vitamin D, a common food additive, has been shown to prevent the induction of experimental autoimmune diseases in mice. A possible immune deviation from T(H)1 to T(H)2 responses has been postulated. Although there is no doubt about the beneficial effects of vitamin D, its role in allergy has not been investigated. OBJECTIVE: To define the role of vitamin D in modulating the development of a T(H)2-mediated disease, we used a murine model of pulmonary eosinophilic inflammation. METHODS: Five-week-old mice were primed on day 0 with ovalbumin intraperitoneally. Then they were nasally challenged with ovalbumin on days 7, 8, 9, and 10, and on day 11, samples were studied. Some mice received subcutaneous injections of vitamin D every second day as follows: days -3, -1, 1, 3, 5, 7, and 9. The control groups received PBS on the same days. RESULTS: Early treatment with vitamin D augmented allergen-induced T-cell proliferation along with T(H)2 cytokine (IL-4 and IL-13) and IgE production. Surprisingly, the local inflammatory response in bronchoalveolar lavage fluid and lung tissue was significantly ameliorated with impaired recruitment of eosinophils and inferior levels of IL-5. These findings were attributed to late treatment with vitamin D after establishment of an early immune response. CONCLUSION: We suggest that excess supplementation of vitamin D could influence the development of a sustained T(H)2 response, leading to an increasing prevalence of allergy, whereas vitamin D might hold promising beneficial effects in airway eosinophilia.

AB - BACKGROUND: Vitamin D, a common food additive, has been shown to prevent the induction of experimental autoimmune diseases in mice. A possible immune deviation from T(H)1 to T(H)2 responses has been postulated. Although there is no doubt about the beneficial effects of vitamin D, its role in allergy has not been investigated. OBJECTIVE: To define the role of vitamin D in modulating the development of a T(H)2-mediated disease, we used a murine model of pulmonary eosinophilic inflammation. METHODS: Five-week-old mice were primed on day 0 with ovalbumin intraperitoneally. Then they were nasally challenged with ovalbumin on days 7, 8, 9, and 10, and on day 11, samples were studied. Some mice received subcutaneous injections of vitamin D every second day as follows: days -3, -1, 1, 3, 5, 7, and 9. The control groups received PBS on the same days. RESULTS: Early treatment with vitamin D augmented allergen-induced T-cell proliferation along with T(H)2 cytokine (IL-4 and IL-13) and IgE production. Surprisingly, the local inflammatory response in bronchoalveolar lavage fluid and lung tissue was significantly ameliorated with impaired recruitment of eosinophils and inferior levels of IL-5. These findings were attributed to late treatment with vitamin D after establishment of an early immune response. CONCLUSION: We suggest that excess supplementation of vitamin D could influence the development of a sustained T(H)2 response, leading to an increasing prevalence of allergy, whereas vitamin D might hold promising beneficial effects in airway eosinophilia.

M3 - Journal article

C2 - 13679819

SN - 0091-6749

VL - 112

SP - 585

EP - 592

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 3

ER -