Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?

Paul E. Verweij; Maiken C. Arendrup; Ana Alastruey-Izquierdo; Jeremy A.W. Gold; Shawn R. Lockhart; Tom Chiller; P. Lewis White

doi:10.1016/j.drup.2022.100885

Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?

Paul E. Verweij^*, Maiken C. Arendrup, Ana Alastruey-Izquierdo, Jeremy A.W. Gold, Shawn R. Lockhart, Tom Chiller, P. Lewis White

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

31 Citationer (Scopus)

11 Downloads (Pure)

Abstract

Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for risk assessment for dual use of antifungals.

Originalsprog	Engelsk
Artikelnummer	100885
Tidsskrift	Drug Resistance Updates
Vol/bind	65
ISSN	1368-7646
DOI	https://doi.org/10.1016/j.drup.2022.100885
Status	Udgivet - 2022

Bibliografisk note

Publisher Copyright:
© 2022 The Authors

Adgang til dokumentet

10.1016/j.drup.2022.100885Licens: CC BY

FulltextForlagets udgivne version, 347 KBLicens: CC BY

Citationsformater

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title = "Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?",

abstract = "Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for risk assessment for dual use of antifungals.",

keywords = "Aspergillus fumigatus, DHODH inhibitor, olorofim, One Health, triazole resistance",

author = "Verweij, {Paul E.} and Arendrup, {Maiken C.} and Ana Alastruey-Izquierdo and Gold, {Jeremy A.W.} and Lockhart, {Shawn R.} and Tom Chiller and White, {P. Lewis}",

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year = "2022",

doi = "10.1016/j.drup.2022.100885",

language = "English",

volume = "65",

journal = "Drug Resistance Updates",

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TY - JOUR

T1 - Dual use of antifungals in medicine and agriculture

T2 - How do we help prevent resistance developing in human pathogens?

AU - Verweij, Paul E.

AU - Arendrup, Maiken C.

AU - Alastruey-Izquierdo, Ana

AU - Gold, Jeremy A.W.

AU - Lockhart, Shawn R.

AU - Chiller, Tom

AU - White, P. Lewis

PY - 2022

Y1 - 2022

N2 - Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for risk assessment for dual use of antifungals.

AB - Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for risk assessment for dual use of antifungals.

KW - Aspergillus fumigatus

KW - DHODH inhibitor

KW - olorofim

KW - One Health

KW - triazole resistance

U2 - 10.1016/j.drup.2022.100885

DO - 10.1016/j.drup.2022.100885

M3 - Journal article

C2 - 36283187

AN - SCOPUS:85140326308

SN - 1368-7646

VL - 65

JO - Drug Resistance Updates

JF - Drug Resistance Updates

M1 - 100885

ER -