Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Neuropsychobiology |
| Vol/bind | 60 |
| Udgave nummer | 1 |
| Sider (fra-til) | 31-6 |
| Antal sider | 5 |
| ISSN | 0302-282X |
| DOI | |
| Status | Udgivet - 2009 |
Bibliografisk note
Copyright 2009 S. Karger AG, Basel.Adgang til dokumentet
Citationsformater
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
I: Neuropsychobiology, Bind 60, Nr. 1, 2009, s. 31-6.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - Dysbindin and d-amino-acid-oxidase gene polymorphisms associated with positive and negative symptoms in schizophrenia
AU - Wirgenes, Katrine V
AU - Djurovic, Srdjan
AU - Agartz, Ingrid
AU - Jonsson, Erik G
AU - Werge, Thomas
AU - Melle, Ingrid
AU - Andreassen, Ole A
AU - Wirgenes, Katrine V
AU - Djurovic, Srdjan
AU - Agartz, Ingrid
AU - Jonsson, Erik G
AU - Werge, Thomas
AU - Melle, Ingrid
AU - Andreassen, Ole A
N1 - Keywords: Adult; Analysis of Variance; Anxiety; Carrier Proteins; D-Amino-Acid Oxidase; Depression; Gene Frequency; Genetic Association Studies; Genotype; Humans; Interviews as Topic; Male; Norway; Phenotype; Polymorphism, Single Nucleotide; Schizophrenia; Schizophrenic Psychology; Sequence Analysis, DNA; Severity of Illness Index
PY - 2009
Y1 - 2009
N2 - BACKGROUND: Schizophrenia is a genetically complex disorder with an unknown pathophysiology. Several genes implicated in glutamate metabolism have been associated with the disorder. Recent studies of polymorphisms in the dystrobrevin-binding protein 1 gene (DTNBP1; dysbindin) and D-amino-acid-oxidase (DAO) gene, both involved in glutamate receptor function, reported associations with negative symptoms and with anxiety and depression, respectively, when measured with the Positive and Negative Syndrome Scale (PANSS). METHODS: In the present study, the suggested association between dysbindin and DAO single nucleotide polymorphisms (SNPs) and PANSS scores was analyzed in 155 Norwegian schizophrenia patients. RESULTS: There was a significant association between the dysbindin SNP rs3213207 and severity of both negative symptoms and total symptom load, as well as between the DAO SNP rs2070587 and total symptom score and severity of anxiety and depression. CONCLUSION: The present association of dysbindin SNPs with negative symptoms and DAO SNPs with anxiety and depression is a replication of earlier findings and strengthens the hypothesis of a genetic association. It further indicates involvement of glutamate abnormalities in schizophrenia pathophysiology, as suggested by previous studies, and suggests that polymorphisms may be associated with subgroups of clinical characteristics in schizophrenia.
AB - BACKGROUND: Schizophrenia is a genetically complex disorder with an unknown pathophysiology. Several genes implicated in glutamate metabolism have been associated with the disorder. Recent studies of polymorphisms in the dystrobrevin-binding protein 1 gene (DTNBP1; dysbindin) and D-amino-acid-oxidase (DAO) gene, both involved in glutamate receptor function, reported associations with negative symptoms and with anxiety and depression, respectively, when measured with the Positive and Negative Syndrome Scale (PANSS). METHODS: In the present study, the suggested association between dysbindin and DAO single nucleotide polymorphisms (SNPs) and PANSS scores was analyzed in 155 Norwegian schizophrenia patients. RESULTS: There was a significant association between the dysbindin SNP rs3213207 and severity of both negative symptoms and total symptom load, as well as between the DAO SNP rs2070587 and total symptom score and severity of anxiety and depression. CONCLUSION: The present association of dysbindin SNPs with negative symptoms and DAO SNPs with anxiety and depression is a replication of earlier findings and strengthens the hypothesis of a genetic association. It further indicates involvement of glutamate abnormalities in schizophrenia pathophysiology, as suggested by previous studies, and suggests that polymorphisms may be associated with subgroups of clinical characteristics in schizophrenia.
U2 - 10.1159/000235799
DO - 10.1159/000235799
M3 - Journal article
C2 - 19729970
SN - 0302-282X
VL - 60
SP - 31
EP - 36
JO - Neuropsychobiology
JF - Neuropsychobiology
IS - 1
ER -