Early experience in avoiding biopsies for biopsy-naive men with clinical suspicion of prostate cancer but non-suspicious biparametric magnetic resonance imaging results and prostate-specific antigen density < 0.15 ng/mL2: A 2-year follow-up study

Karen-Cecilie Kortenbach*, Vibeke Logager, Henrik S. Thomsen, Lars Boesen

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Abstract

Background: Only limited data have been published on the diagnostic accuracy of combining biparametric (bp) magnetic resonance imaging (MRI) and prostate-specific antigen density (PSAd) to rule out biopsies.

Purpose: The purpose is to assess the 2-year risk of being diagnosed with sPCa following the strategy of avoiding immediate biopsies in men with non-suspicious bp MRIs and a PSAd

Material and Methods: Two hundred biopsy-naive men with clinical suspicion of PCa underwent a pre-biopsy bp MRI from March to July 2019. Of these, 109 men had a Prostate Imaging Reporting and Data System (PI-RADS) score of 1-3 including 77 men with calculated PSAd = 0.15 ng/mL(2) underwent systematic biopsies and targeted biopsies of any PI-RADS 3 lesion.

Results: One of the 77 men (1.3%) had an sPCa diagnosed within 2 years of follow-up. All men were referred back to their general practitioner within 1 year and 9% (7/77) were re-referred to the urology department during follow-up. Among these men, 43% (3/7) continued to have PSA levels that were above their individual thresholds at confirmatory testing and underwent secondary MRI scans.

Conclusions: No biopsies for men with bpMRI results exhibiting maximum PI-RADS 3 and with a PSAd

OriginalsprogEngelsk
Artikelnummer20584601221094825
TidsskriftActa Radiologica Open
Vol/bind11
Udgave nummer4
Antal sider9
ISSN2047-9816
DOI
StatusUdgivet - 2022

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