Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children

Evelien R van Meel; Sara M Mensink-Bout; Herman T den Dekker; Tarunveer S Ahluwalia; Isabella Annesi-Maesano; Syed Hasan Arshad; Nour Baïz; Henrique Barros; Andrea von Berg; Hans Bisgaard; Klaus Bønnelykke; Christian J Carlsson; Maribel Casas; Leda Chatzi; Cecile Chevrier; Geertje Dalmeijer; Carol Dezateux; Karel Duchen; Merete Eggesbø; Cornelis van der Ent; Maria Fantini; Claudia Flexeder; Urs Frey; Fransesco Forastiere; Ulrike Gehring; Davide Gori; Raquel Granell; Lucy J Griffiths; Hazel Inskip; Joanna Jerzynska; Anne M Karvonen; Thomas Keil; Cecily Kelleher; Manolis Kogevinas; Gudrun Koppen; Claudia E Kuehni; Nathalie Lambrechts; Susanne Lau; Irina Lehmann; Johnny Ludvigsson; Maria Christine Magnus; Erik Mélen; John Mehegan; Monique Mommers; Anne-Marie Nybo Andersen; Wenche Nystad; Eva S L Pedersen; Juha Pekkanen; Ville Peltola; Angela Pinot de Moira; LifeCycle Project Group

doi:10.1183/13993003.02395-2021

Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children

Evelien R van Meel, Sara M Mensink-Bout, Herman T den Dekker, Tarunveer S Ahluwalia, Isabella Annesi-Maesano, Syed Hasan Arshad, Nour Baïz, Henrique Barros, Andrea von Berg, Hans Bisgaard, Klaus Bønnelykke, Christian J Carlsson, Maribel Casas, Leda Chatzi, Cecile Chevrier, Geertje Dalmeijer, Carol Dezateux, Karel Duchen, Merete Eggesbø, Cornelis van der EntMaria Fantini, Claudia Flexeder, Urs Frey, Fransesco Forastiere, Ulrike Gehring, Davide Gori, Raquel Granell, Lucy J Griffiths, Hazel Inskip, Joanna Jerzynska, Anne M Karvonen, Thomas Keil, Cecily Kelleher, Manolis Kogevinas, Gudrun Koppen, Claudia E Kuehni, Nathalie Lambrechts, Susanne Lau, Irina Lehmann, Johnny Ludvigsson, Maria Christine Magnus, Erik Mélen, John Mehegan, Monique Mommers, Anne-Marie Nybo Andersen, Wenche Nystad, Eva S L Pedersen, Juha Pekkanen, Ville Peltola, Angela Pinot de Moira, LifeCycle Project Group

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

42 Citationer (Scopus)

Abstract

BACKGROUND: Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking.

OBJECTIVE: To examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school-age.

METHODS: We used individual-participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow at 75% of FVC (FEF75), and asthma at a median age of 7 (range 4 to 15) years.

RESULTS: Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV1, FEV1/FVC and FEF75 (Z-score (95% CI): ranging from -0.09 (-0.14, -0.04) to -0.30 (-0.36, -0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR (95%CI): ranging from 2.10 (1.98, 2.22) to 6.30 (5.64, 7.04)), and from 1.25 (1.18, 1.32) to 1.55 (1.47, 1.65)), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as proxy for early-life asthma.

CONCLUSION: Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower upper respiratory tract infections.

Originalsprog	Engelsk
Tidsskrift	The European respiratory journal
Vol/bind	60
Udgave nummer	2
Antal sider	65
ISSN	0903-1936
DOI	https://doi.org/10.1183/13993003.02395-2021
Status	Udgivet - 2022

Bibliografisk note

Adgang til dokumentet

10.1183/13993003.02395-2021

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535116/pdf/ERJ-02395-2021.pdfLicens: Andet

Citationsformater

van Meel, E. R., Mensink-Bout, S. M., den Dekker, H. T., Ahluwalia, T. S., Annesi-Maesano, I., Arshad, S. H., Baïz, N., Barros, H., von Berg, A., Bisgaard, H., Bønnelykke, K., Carlsson, C. J., Casas, M., Chatzi, L., Chevrier, C., Dalmeijer, G., Dezateux, C., Duchen, K., Eggesbø, M., ... LifeCycle Project Group (2022). Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children. The European respiratory journal, 60(2). https://doi.org/10.1183/13993003.02395-2021

Early-life respiratory tract infections and the risk of school-age lower lung function and asthma : a meta-analysis of 150 000 European children. / van Meel, Evelien R; Mensink-Bout, Sara M; den Dekker, Herman T; Ahluwalia, Tarunveer S; Annesi-Maesano, Isabella; Arshad, Syed Hasan; Baïz, Nour; Barros, Henrique; von Berg, Andrea; Bisgaard, Hans; Bønnelykke, Klaus; Carlsson, Christian J; Casas, Maribel; Chatzi, Leda; Chevrier, Cecile; Dalmeijer, Geertje; Dezateux, Carol; Duchen, Karel; Eggesbø, Merete; van der Ent, Cornelis; Fantini, Maria; Flexeder, Claudia; Frey, Urs; Forastiere, Fransesco; Gehring, Ulrike; Gori, Davide; Granell, Raquel; Griffiths, Lucy J; Inskip, Hazel; Jerzynska, Joanna; Karvonen, Anne M; Keil, Thomas; Kelleher, Cecily; Kogevinas, Manolis; Koppen, Gudrun; Kuehni, Claudia E; Lambrechts, Nathalie; Lau, Susanne; Lehmann, Irina; Ludvigsson, Johnny; Magnus, Maria Christine; Mélen, Erik; Mehegan, John; Mommers, Monique; Andersen, Anne-Marie Nybo; Nystad, Wenche; Pedersen, Eva S L; Pekkanen, Juha; Peltola, Ville; de Moira, Angela Pinot; LifeCycle Project Group.

I: The European respiratory journal, Bind 60, Nr. 2, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

van Meel, ER, Mensink-Bout, SM, den Dekker, HT, Ahluwalia, TS, Annesi-Maesano, I, Arshad, SH, Baïz, N, Barros, H, von Berg, A, Bisgaard, H, Bønnelykke, K, Carlsson, CJ, Casas, M, Chatzi, L, Chevrier, C, Dalmeijer, G, Dezateux, C, Duchen, K, Eggesbø, M, van der Ent, C, Fantini, M, Flexeder, C, Frey, U, Forastiere, F, Gehring, U, Gori, D, Granell, R, Griffiths, LJ, Inskip, H, Jerzynska, J, Karvonen, AM, Keil, T, Kelleher, C, Kogevinas, M, Koppen, G, Kuehni, CE, Lambrechts, N, Lau, S, Lehmann, I, Ludvigsson, J, Magnus, MC, Mélen, E, Mehegan, J, Mommers, M, Andersen, A-MN, Nystad, W, Pedersen, ESL, Pekkanen, J, Peltola, V, de Moira, AP & LifeCycle Project Group 2022, 'Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children', The European respiratory journal, bind 60, nr. 2. https://doi.org/10.1183/13993003.02395-2021

van Meel, Evelien R ; Mensink-Bout, Sara M ; den Dekker, Herman T ; Ahluwalia, Tarunveer S ; Annesi-Maesano, Isabella ; Arshad, Syed Hasan ; Baïz, Nour ; Barros, Henrique ; von Berg, Andrea ; Bisgaard, Hans ; Bønnelykke, Klaus ; Carlsson, Christian J ; Casas, Maribel ; Chatzi, Leda ; Chevrier, Cecile ; Dalmeijer, Geertje ; Dezateux, Carol ; Duchen, Karel ; Eggesbø, Merete ; van der Ent, Cornelis ; Fantini, Maria ; Flexeder, Claudia ; Frey, Urs ; Forastiere, Fransesco ; Gehring, Ulrike ; Gori, Davide ; Granell, Raquel ; Griffiths, Lucy J ; Inskip, Hazel ; Jerzynska, Joanna ; Karvonen, Anne M ; Keil, Thomas ; Kelleher, Cecily ; Kogevinas, Manolis ; Koppen, Gudrun ; Kuehni, Claudia E ; Lambrechts, Nathalie ; Lau, Susanne ; Lehmann, Irina ; Ludvigsson, Johnny ; Magnus, Maria Christine ; Mélen, Erik ; Mehegan, John ; Mommers, Monique ; Andersen, Anne-Marie Nybo ; Nystad, Wenche ; Pedersen, Eva S L ; Pekkanen, Juha ; Peltola, Ville ; de Moira, Angela Pinot ; LifeCycle Project Group. / Early-life respiratory tract infections and the risk of school-age lower lung function and asthma : a meta-analysis of 150 000 European children. I: The European respiratory journal. 2022 ; Bind 60, Nr. 2.

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title = "Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children",

abstract = "BACKGROUND: Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking.OBJECTIVE: To examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school-age.METHODS: We used individual-participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow at 75% of FVC (FEF75), and asthma at a median age of 7 (range 4 to 15) years.RESULTS: Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV1, FEV1/FVC and FEF75 (Z-score (95% CI): ranging from -0.09 (-0.14, -0.04) to -0.30 (-0.36, -0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR (95%CI): ranging from 2.10 (1.98, 2.22) to 6.30 (5.64, 7.04)), and from 1.25 (1.18, 1.32) to 1.55 (1.47, 1.65)), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as proxy for early-life asthma.CONCLUSION: Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower upper respiratory tract infections.",

author = "{van Meel}, {Evelien R} and Mensink-Bout, {Sara M} and {den Dekker}, {Herman T} and Ahluwalia, {Tarunveer S} and Isabella Annesi-Maesano and Arshad, {Syed Hasan} and Nour Ba{\"i}z and Henrique Barros and {von Berg}, Andrea and Hans Bisgaard and Klaus B{\o}nnelykke and Carlsson, {Christian J} and Maribel Casas and Leda Chatzi and Cecile Chevrier and Geertje Dalmeijer and Carol Dezateux and Karel Duchen and Merete Eggesb{\o} and {van der Ent}, Cornelis and Maria Fantini and Claudia Flexeder and Urs Frey and Fransesco Forastiere and Ulrike Gehring and Davide Gori and Raquel Granell and Griffiths, {Lucy J} and Hazel Inskip and Joanna Jerzynska and Karvonen, {Anne M} and Thomas Keil and Cecily Kelleher and Manolis Kogevinas and Gudrun Koppen and Kuehni, {Claudia E} and Nathalie Lambrechts and Susanne Lau and Irina Lehmann and Johnny Ludvigsson and Magnus, {Maria Christine} and Erik M{\'e}len and John Mehegan and Monique Mommers and Andersen, {Anne-Marie Nybo} and Wenche Nystad and Pedersen, {Eva S L} and Juha Pekkanen and Ville Peltola and {de Moira}, {Angela Pinot} and {LifeCycle Project Group}",

note = "Copyright {\textcopyright}The authors 2022. For reproduction rights and permissions contact [email protected].",

year = "2022",

doi = "10.1183/13993003.02395-2021",

language = "English",

volume = "60",

journal = "The European respiratory journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "2",

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TY - JOUR

T1 - Early-life respiratory tract infections and the risk of school-age lower lung function and asthma

T2 - a meta-analysis of 150 000 European children

AU - van Meel, Evelien R

AU - Mensink-Bout, Sara M

AU - den Dekker, Herman T

AU - Ahluwalia, Tarunveer S

AU - Annesi-Maesano, Isabella

AU - Arshad, Syed Hasan

AU - Baïz, Nour

AU - Barros, Henrique

AU - von Berg, Andrea

AU - Bisgaard, Hans

AU - Bønnelykke, Klaus

AU - Carlsson, Christian J

AU - Casas, Maribel

AU - Chatzi, Leda

AU - Chevrier, Cecile

AU - Dalmeijer, Geertje

AU - Dezateux, Carol

AU - Duchen, Karel

AU - Eggesbø, Merete

AU - van der Ent, Cornelis

AU - Fantini, Maria

AU - Flexeder, Claudia

AU - Frey, Urs

AU - Forastiere, Fransesco

AU - Gehring, Ulrike

AU - Gori, Davide

AU - Granell, Raquel

AU - Griffiths, Lucy J

AU - Inskip, Hazel

AU - Jerzynska, Joanna

AU - Karvonen, Anne M

AU - Keil, Thomas

AU - Kelleher, Cecily

AU - Kogevinas, Manolis

AU - Koppen, Gudrun

AU - Kuehni, Claudia E

AU - Lambrechts, Nathalie

AU - Lau, Susanne

AU - Lehmann, Irina

AU - Ludvigsson, Johnny

AU - Magnus, Maria Christine

AU - Mélen, Erik

AU - Mehegan, John

AU - Mommers, Monique

AU - Andersen, Anne-Marie Nybo

AU - Nystad, Wenche

AU - Pedersen, Eva S L

AU - Pekkanen, Juha

AU - Peltola, Ville

AU - de Moira, Angela Pinot

AU - LifeCycle Project Group

PY - 2022

Y1 - 2022

N2 - BACKGROUND: Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking.OBJECTIVE: To examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school-age.METHODS: We used individual-participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow at 75% of FVC (FEF75), and asthma at a median age of 7 (range 4 to 15) years.RESULTS: Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV1, FEV1/FVC and FEF75 (Z-score (95% CI): ranging from -0.09 (-0.14, -0.04) to -0.30 (-0.36, -0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR (95%CI): ranging from 2.10 (1.98, 2.22) to 6.30 (5.64, 7.04)), and from 1.25 (1.18, 1.32) to 1.55 (1.47, 1.65)), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as proxy for early-life asthma.CONCLUSION: Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower upper respiratory tract infections.

AB - BACKGROUND: Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking.OBJECTIVE: To examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school-age.METHODS: We used individual-participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow at 75% of FVC (FEF75), and asthma at a median age of 7 (range 4 to 15) years.RESULTS: Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV1, FEV1/FVC and FEF75 (Z-score (95% CI): ranging from -0.09 (-0.14, -0.04) to -0.30 (-0.36, -0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR (95%CI): ranging from 2.10 (1.98, 2.22) to 6.30 (5.64, 7.04)), and from 1.25 (1.18, 1.32) to 1.55 (1.47, 1.65)), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as proxy for early-life asthma.CONCLUSION: Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower upper respiratory tract infections.

U2 - 10.1183/13993003.02395-2021

DO - 10.1183/13993003.02395-2021

M3 - Journal article

C2 - 35487537

VL - 60

JO - The European respiratory journal

JF - The European respiratory journal

SN - 0903-1936

IS - 2

ER -