@article{d223c0304dc411dd8d9f000ea68e967b,
title = "Editing modifies the GABA(A) receptor subunit alpha3.",
abstract = "Adenosine to inosine (A-to-I) pre-mRNA editing by the ADAR enzyme family has the potential to increase the variety of the proteome. This editing by adenosine deamination is essential in mammals for a functional brain. To detect novel substrates for A-to-I editing we have used an experimental method to find selectively edited sites and combined it with bioinformatic techniques that find stem-loop structures suitable for editing. We present here the first verified editing candidate detected by this screening procedure. We show that Gabra-3, which codes for the alpha3 subunit of the GABA(A) receptor, is a substrate for editing by both ADAR1 and ADAR2. Editing of the Gabra-3 mRNA recodes an isoleucine to a methionine. The extent of editing is low at birth but increases with age, reaching close to 100% in the adult brain. We therefore propose that editing of the Gabra-3 mRNA is important for normal brain development.",
author = "Johan Ohlson and Pedersen, {Jakob Skou} and David Haussler and Marie Ohman",
note = "Keywords: Adenosine Deaminase; Animals; Animals, Newborn; Brain; Cells, Cultured; Gene Expression Regulation, Developmental; Humans; Isoleucine; Methionine; Mice; Mice, Inbred Strains; Mice, Mutant Strains; RNA Editing; Receptors, GABA-A",
year = "2007",
doi = "10.1261/rna.349107",
language = "English",
volume = "13",
pages = "698--703",
journal = "RNA: A publication of the RNA Society",
issn = "1355-8382",
publisher = "Cold Spring Harbor Laboratory Press",
number = "5",
}