Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Twin Research and Human Genetics |
| Vol/bind | 20 |
| Udgave nummer | 5 |
| Sider (fra-til) | 395-405 |
| Antal sider | 11 |
| ISSN | 1832-4274 |
| DOI | |
| Status | Udgivet - okt. 2017 |
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Education in Twins and Their Parents Across Birth Cohorts Over 100 years : An Individual-Level Pooled Analysis of 42-Twin Cohorts. / Silventoinen, Karri; Jelenkovic, Aline; Latvala, Antti; Sund, Reijo; Yokoyama, Yoshie; Ullemar, Vilhelmina; Almqvist, Catarina; Derom, Catherine A.; Vlietinck, Robert F.; Loos, Ruth J. F.; Kandler, Christian; Honda, Chika; Inui, Fujio; Iwatani, Yoshinori; Watanabe, Mikio; Rebato, Esther; Stazi, Maria A.; Fagnani, Corrado; Brescianini, Sonia; Hur, Yoon-Mi; Jeong, Hoe-Uk; Cutler, Tessa L.; Hopper, John L.; Busjahn, Andreas; Saudino, Kimberly J.; Ji, Fuling; Ning, Feng; Pang, Zengchang; Rose, Richard J.; Koskenvuo, Markku; Heikkilae, Kauko; Cozen, Wendy; Hwang, Amie E.; Mack, Thomas M.; Siribaddana, Sisira H.; Hotopf, Matthew; Sumathipala, Athula; Rijsdijk, Fruhling; Sung, Joohon; Kim, Jina; Lee, Jooyeon; Lee, Sooji; Nelson, Tracy L.; Whitfield, Keith E.; Tan, Qihua; Zhang, Dongfeng; Llewellyn, Clare H.; Fisher, Abigail; Burt, S. Alexandra; Klump, Kelly L.; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Medland, Sarah E.; Martin, Nicholas G.; Montgomery, Grant W.; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Aslan, Anna K. Dahl; Corley, Robin P.; Huibregtse, Brooke M.; OEncel, Sevgi Y.; Aliev, Fazil; Krueger, Robert F.; Mcgue, Matt; Pahlen, Shandell; Willemsen, Gonneke; Bartels, Meike; Van Beijsterveldt, Catharina E. M.; Silberg, Judy L.; Eaves, Lindon J.; Maes, Hermine H.; Harris, Jennifer R.; Brandt, Ingunn; Nilsen, Thomas S.; Rasmussen, Finn; Tynelius, Per; Baker, Laura A.; Tuvblad, Catherine; Ordonana, Juan R.; Sanchez-Romera, Juan F.; Colodro-Conde, Lucia; Gatz, Margaret; Butler, David A.; Lichtenstein, Paul; Goldberg, Jack H.; Harden, K. Paige; Tucker-Drob, Elliot M.; Duncan, Glen E.; Buchwald, Dedra; Tarnoki, Adam D.; Tarnoki, David L.; Franz, Carol E.; Kremen, William S.; Lyons, Michael J.; Maia, Jose A.; Freitas, Duarte L.; Turkheimer, Eric; Sørensen, Thorkild I. A.; Boomsma, Dorret I.; Kaprio, Jaakko.
I: Twin Research and Human Genetics, Bind 20, Nr. 5, 10.2017, s. 395-405.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - Education in Twins and Their Parents Across Birth Cohorts Over 100 years
T2 - An Individual-Level Pooled Analysis of 42-Twin Cohorts
AU - Silventoinen, Karri
AU - Jelenkovic, Aline
AU - Latvala, Antti
AU - Sund, Reijo
AU - Yokoyama, Yoshie
AU - Ullemar, Vilhelmina
AU - Almqvist, Catarina
AU - Derom, Catherine A.
AU - Vlietinck, Robert F.
AU - Loos, Ruth J. F.
AU - Kandler, Christian
AU - Honda, Chika
AU - Inui, Fujio
AU - Iwatani, Yoshinori
AU - Watanabe, Mikio
AU - Rebato, Esther
AU - Stazi, Maria A.
AU - Fagnani, Corrado
AU - Brescianini, Sonia
AU - Hur, Yoon-Mi
AU - Jeong, Hoe-Uk
AU - Cutler, Tessa L.
AU - Hopper, John L.
AU - Busjahn, Andreas
AU - Saudino, Kimberly J.
AU - Ji, Fuling
AU - Ning, Feng
AU - Pang, Zengchang
AU - Rose, Richard J.
AU - Koskenvuo, Markku
AU - Heikkilae, Kauko
AU - Cozen, Wendy
AU - Hwang, Amie E.
AU - Mack, Thomas M.
AU - Siribaddana, Sisira H.
AU - Hotopf, Matthew
AU - Sumathipala, Athula
AU - Rijsdijk, Fruhling
AU - Sung, Joohon
AU - Kim, Jina
AU - Lee, Jooyeon
AU - Lee, Sooji
AU - Nelson, Tracy L.
AU - Whitfield, Keith E.
AU - Tan, Qihua
AU - Zhang, Dongfeng
AU - Llewellyn, Clare H.
AU - Fisher, Abigail
AU - Burt, S. Alexandra
AU - Klump, Kelly L.
AU - Knafo-Noam, Ariel
AU - Mankuta, David
AU - Abramson, Lior
AU - Medland, Sarah E.
AU - Martin, Nicholas G.
AU - Montgomery, Grant W.
AU - Magnusson, Patrik K. E.
AU - Pedersen, Nancy L.
AU - Aslan, Anna K. Dahl
AU - Corley, Robin P.
AU - Huibregtse, Brooke M.
AU - OEncel, Sevgi Y.
AU - Aliev, Fazil
AU - Krueger, Robert F.
AU - Mcgue, Matt
AU - Pahlen, Shandell
AU - Willemsen, Gonneke
AU - Bartels, Meike
AU - Van Beijsterveldt, Catharina E. M.
AU - Silberg, Judy L.
AU - Eaves, Lindon J.
AU - Maes, Hermine H.
AU - Harris, Jennifer R.
AU - Brandt, Ingunn
AU - Nilsen, Thomas S.
AU - Rasmussen, Finn
AU - Tynelius, Per
AU - Baker, Laura A.
AU - Tuvblad, Catherine
AU - Ordonana, Juan R.
AU - Sanchez-Romera, Juan F.
AU - Colodro-Conde, Lucia
AU - Gatz, Margaret
AU - Butler, David A.
AU - Lichtenstein, Paul
AU - Goldberg, Jack H.
AU - Harden, K. Paige
AU - Tucker-Drob, Elliot M.
AU - Duncan, Glen E.
AU - Buchwald, Dedra
AU - Tarnoki, Adam D.
AU - Tarnoki, David L.
AU - Franz, Carol E.
AU - Kremen, William S.
AU - Lyons, Michael J.
AU - Maia, Jose A.
AU - Freitas, Duarte L.
AU - Turkheimer, Eric
AU - Sørensen, Thorkild I. A.
AU - Boomsma, Dorret I.
AU - Kaprio, Jaakko
PY - 2017/10
Y1 - 2017/10
N2 - Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for 147,315 and 143,056 twins respectively, from 28 twin cohorts (52% females; 38% MZ twins). Together, we had information on individual or parental education from 42 twin cohorts representing 19 countries. The original education classifications were transformed to education years and analyzed using linear regression models. Overall, MZ males had 0.26 (95% CI [0.21, 0.31]) years and MZ females 0.17 (95% CI [0.12, 0.21]) years longer education than DZ twins. The zygosity difference became smaller in more recent birth cohorts for both males and females. Parental education was somewhat longer for fathers of DZ twins in cohorts born in 1990–1999 (0.16 years, 95% CI [0.08, 0.25]) and 2000 or later (0.11 years, 95% CI [0.00, 0.22]), compared with fathers of MZ twins. The results show that the years of both individual and parental education are largely similar in MZ and DZ twins. We suggest that the socio-economic differences between MZ and DZ twins are so small that inferences based upon genetic modeling of twin data are not affected.
AB - Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for 147,315 and 143,056 twins respectively, from 28 twin cohorts (52% females; 38% MZ twins). Together, we had information on individual or parental education from 42 twin cohorts representing 19 countries. The original education classifications were transformed to education years and analyzed using linear regression models. Overall, MZ males had 0.26 (95% CI [0.21, 0.31]) years and MZ females 0.17 (95% CI [0.12, 0.21]) years longer education than DZ twins. The zygosity difference became smaller in more recent birth cohorts for both males and females. Parental education was somewhat longer for fathers of DZ twins in cohorts born in 1990–1999 (0.16 years, 95% CI [0.08, 0.25]) and 2000 or later (0.11 years, 95% CI [0.00, 0.22]), compared with fathers of MZ twins. The results show that the years of both individual and parental education are largely similar in MZ and DZ twins. We suggest that the socio-economic differences between MZ and DZ twins are so small that inferences based upon genetic modeling of twin data are not affected.
KW - twins
KW - zygosity
KW - education
KW - parental education
U2 - 10.1017/thg.2017.49
DO - 10.1017/thg.2017.49
M3 - Journal article
C2 - 28975875
VL - 20
SP - 395
EP - 405
JO - Acta Geneticae Medicae et Gemellologiae
JF - Acta Geneticae Medicae et Gemellologiae
SN - 1832-4274
IS - 5
ER -