TY - JOUR
T1 - Effect of bariatric surgery on plasma GDF15 in humans
AU - Kleinert, Maximilian
AU - Bojsen-Møller, Kirstine N
AU - Jørgensen, Nils B
AU - Svane, Maria S
AU - Martinussen, Christoffer
AU - Kiens, Bente
AU - Wojtaszewski, Jørgen
AU - Madsbad, Sten
AU - Richter, Erik A.
AU - Clemmensen, Christoffer
N1 - CURIS 2019 NEXS 124
PY - 2019
Y1 - 2019
N2 - Bariatric surgery results in marked body weight loss and improves type 2 diabetes in most patients with obesity. The growth differentiation factor 15 (GDF15) has recently emerged as a novel satiety factor. To begin to understand whether GDF15 is involved in mediating the effects of bariatric surgery on body weight and glycaemia in humans, we measured plasma GDF15 in patients with obesity (n = 25) and in patients with obesity and diabetes (n = 22) before and after Roux-en-Y gastric bypass (RYGB) surgery. GDF15 was increased 1 week after RYGB compared with before surgery (689 ± 45 pg/ml vs. 487 ± 28 pg/ml, P < 0.001) and GDF15 remained elevated at 3 months (554 ± 37 pg/ml, P < 0.05), at 1 year (566 ± 37 pg/ml, P < 0.05) and at 2.5-4 years (630 ± 50 pg/ml, P < 0.001) after RYGB surgery. Both age and insulin sensitivity correlated with GDF15 before the surgery (r = 0.46, P < 0.0001 and r = 0.34, P < 0.001, respectively). These correlations disappeared at 2.5-4 years following the surgery. Conversely, weight loss magnitude correlated with GDF15, measured 2.5-4 years post-surgery (r = 0.21, p<0.0055). In summary, circulating GDF15 increases and correlates with body weight loss following RYGB surgery.
AB - Bariatric surgery results in marked body weight loss and improves type 2 diabetes in most patients with obesity. The growth differentiation factor 15 (GDF15) has recently emerged as a novel satiety factor. To begin to understand whether GDF15 is involved in mediating the effects of bariatric surgery on body weight and glycaemia in humans, we measured plasma GDF15 in patients with obesity (n = 25) and in patients with obesity and diabetes (n = 22) before and after Roux-en-Y gastric bypass (RYGB) surgery. GDF15 was increased 1 week after RYGB compared with before surgery (689 ± 45 pg/ml vs. 487 ± 28 pg/ml, P < 0.001) and GDF15 remained elevated at 3 months (554 ± 37 pg/ml, P < 0.05), at 1 year (566 ± 37 pg/ml, P < 0.05) and at 2.5-4 years (630 ± 50 pg/ml, P < 0.001) after RYGB surgery. Both age and insulin sensitivity correlated with GDF15 before the surgery (r = 0.46, P < 0.0001 and r = 0.34, P < 0.001, respectively). These correlations disappeared at 2.5-4 years following the surgery. Conversely, weight loss magnitude correlated with GDF15, measured 2.5-4 years post-surgery (r = 0.21, p<0.0055). In summary, circulating GDF15 increases and correlates with body weight loss following RYGB surgery.
KW - Faculty of Science
KW - GDF15
KW - Bariatric surgery
KW - Roux-en-Y gastric bypass
KW - Obesity
KW - Diabetes
U2 - 10.1152/ajpendo.00010.2019
DO - 10.1152/ajpendo.00010.2019
M3 - Journal article
C2 - 30721097
VL - 316
SP - E615-E621
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
SN - 0193-1849
IS - 4
ER -