Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial

Robert Tweyongyere, Patrice A. Mawa, Macklyn Kihembo, Frances M. Jones, Emily L. Webb, Stephen Cose, David W. Dunne, Birgitte J Vennervald, Alison M. Elliott

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    Abstract

    Offspring of women with schistosomiasis may exhibit immune responsiveness to schistosomes due to in utero sensitisation or trans-placental transfer of antibodies. Praziquantel treatment during pregnancy boosts maternal immune responses to schistosome antigens and reduces worm burden. Effects of praziquantel treatment during pregnancy on responses among offspring are unknown.
    OriginalsprogEngelsk
    TidsskriftB M C Infectious Diseases
    Vol/bind11
    Udgave nummer234
    Antal sider13
    ISSN1471-2334
    DOI
    StatusUdgivet - 2011

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