Effect of renal venous pressure elevation on tubular sodium and water reabsorption in the dog kidney.

U Abildgaard; O Amtorp; N H Holstein-Rathlou; K Agerskov; E Sjøntoft; N J Christensen; P P Leyssac

Effect of renal venous pressure elevation on tubular sodium and water reabsorption in the dog kidney.

U Abildgaard, O Amtorp, N H Holstein-Rathlou, K Agerskov, E Sjøntoft, N J Christensen, P P Leyssac

Biomedicinsk Institut

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

8 Citationer (Scopus)

Abstract

Udgivelsesdato: 1988-Feb

Originalsprog	Engelsk
Tidsskrift	Acta Physiologica (Print Edition)
Vol/bind	132
Udgave nummer	2
Sider (fra-til)	135-42
Antal sider	7
ISSN	1748-1708
Status	Udgivet - 1988

Bibliografisk note

Keywords: Adrenergic alpha-Antagonists; Amiloride; Animals; Body Water; Denervation; Dogs; Epinephrine; Glomerular Filtration Rate; Kidney; Kidney Tubules; Lithium; Mechanoreceptors; Norepinephrine; Sodium; Venous Pressure

Citationsformater

@article{9dd84c60abed11ddb5e9000ea68e967b,

title = "Effect of renal venous pressure elevation on tubular sodium and water reabsorption in the dog kidney.",

abstract = "This study was performed in order to quantify the effects of renal venous pressure (RVP) elevation on absolute and fractional reabsorption rates of sodium and water in proximal and distal segments of the nephron in dog kidneys. Renal blood flow (RBF) was measured electromagnetically. Clearance of [51Cr]EDTA was used as a measure of the rate of glomerular filtration (GFR). GFR, urinary excretion rates of sodium and water, and lithium clearance were used for assessing the absolute and fractional reabsorption rates of sodium and water in the proximal as well as in more distal segments of the nephron. In the kidneys with intact innervation RVP elevation to 19.9 +/- 0.1 mmHg caused significant increases in both absolute (APR) and fractional (FPR) proximal reabsorption rates from 33.4 +/- 4.2 to 38.7 +/- 2.0 ml min-1 and from 0.62 +/- 0.04 to 0.71 +/- 0.04, respectively. These responses were unaffected by acute surgical denervation of the kidneys. In contrast, chronic renal denervation or infusion of phentolamine (5 micrograms kg-1 min-1) into the renal artery eliminated the increase in APR and FPR during RVP elevation to 20 mmHg. Chronic, but not acute renal denervation depleted renal tissue content of adrenaline and noradrenaline. The results suggest that the increase in APR and FPR during RVP elevation is due mainly to local sympathetic reflex mechanisms.",

author = "U Abildgaard and O Amtorp and Holstein-Rathlou, {N H} and K Agerskov and E Sj{\o}ntoft and Christensen, {N J} and Leyssac, {P P}",

note = "Keywords: Adrenergic alpha-Antagonists; Amiloride; Animals; Body Water; Denervation; Dogs; Epinephrine; Glomerular Filtration Rate; Kidney; Kidney Tubules; Lithium; Mechanoreceptors; Norepinephrine; Sodium; Venous Pressure",

year = "1988",

language = "English",

volume = "132",

pages = "135--42",

journal = "Acta Physiologica",

issn = "1748-1708",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Effect of renal venous pressure elevation on tubular sodium and water reabsorption in the dog kidney.

AU - Abildgaard, U

AU - Amtorp, O

AU - Holstein-Rathlou, N H

AU - Agerskov, K

AU - Sjøntoft, E

AU - Christensen, N J

AU - Leyssac, P P

N1 - Keywords: Adrenergic alpha-Antagonists; Amiloride; Animals; Body Water; Denervation; Dogs; Epinephrine; Glomerular Filtration Rate; Kidney; Kidney Tubules; Lithium; Mechanoreceptors; Norepinephrine; Sodium; Venous Pressure

PY - 1988

Y1 - 1988

N2 - This study was performed in order to quantify the effects of renal venous pressure (RVP) elevation on absolute and fractional reabsorption rates of sodium and water in proximal and distal segments of the nephron in dog kidneys. Renal blood flow (RBF) was measured electromagnetically. Clearance of [51Cr]EDTA was used as a measure of the rate of glomerular filtration (GFR). GFR, urinary excretion rates of sodium and water, and lithium clearance were used for assessing the absolute and fractional reabsorption rates of sodium and water in the proximal as well as in more distal segments of the nephron. In the kidneys with intact innervation RVP elevation to 19.9 +/- 0.1 mmHg caused significant increases in both absolute (APR) and fractional (FPR) proximal reabsorption rates from 33.4 +/- 4.2 to 38.7 +/- 2.0 ml min-1 and from 0.62 +/- 0.04 to 0.71 +/- 0.04, respectively. These responses were unaffected by acute surgical denervation of the kidneys. In contrast, chronic renal denervation or infusion of phentolamine (5 micrograms kg-1 min-1) into the renal artery eliminated the increase in APR and FPR during RVP elevation to 20 mmHg. Chronic, but not acute renal denervation depleted renal tissue content of adrenaline and noradrenaline. The results suggest that the increase in APR and FPR during RVP elevation is due mainly to local sympathetic reflex mechanisms.

AB - This study was performed in order to quantify the effects of renal venous pressure (RVP) elevation on absolute and fractional reabsorption rates of sodium and water in proximal and distal segments of the nephron in dog kidneys. Renal blood flow (RBF) was measured electromagnetically. Clearance of [51Cr]EDTA was used as a measure of the rate of glomerular filtration (GFR). GFR, urinary excretion rates of sodium and water, and lithium clearance were used for assessing the absolute and fractional reabsorption rates of sodium and water in the proximal as well as in more distal segments of the nephron. In the kidneys with intact innervation RVP elevation to 19.9 +/- 0.1 mmHg caused significant increases in both absolute (APR) and fractional (FPR) proximal reabsorption rates from 33.4 +/- 4.2 to 38.7 +/- 2.0 ml min-1 and from 0.62 +/- 0.04 to 0.71 +/- 0.04, respectively. These responses were unaffected by acute surgical denervation of the kidneys. In contrast, chronic renal denervation or infusion of phentolamine (5 micrograms kg-1 min-1) into the renal artery eliminated the increase in APR and FPR during RVP elevation to 20 mmHg. Chronic, but not acute renal denervation depleted renal tissue content of adrenaline and noradrenaline. The results suggest that the increase in APR and FPR during RVP elevation is due mainly to local sympathetic reflex mechanisms.

M3 - Journal article

C2 - 2906498

VL - 132

SP - 135

EP - 142

JO - Acta Physiologica

JF - Acta Physiologica

SN - 1748-1708

IS - 2

ER -