Abstract
The aim of this randomized controlled trial was to eva-luate the wound-healing effect and antimicrobial properties of a novel stabilized hypochlorous acid solution on acute wounds, using a suction blister wound model. One suction blister was raised and de-roofed on each forearm in 20 healthy volunteers. Stabilized hypochlorous acid/control (sterile 0.9% NaCl) solutions were assigned to either wound by randomization. Wounds were irrigated and treated on days 0, 2 and 4. Re-epithelialization was assessed blindly by digital planimetry, and bacterial growth was assessed as the number of colony-forming units cultured from surface swabs. Hypochlorous acid solution increased the de-gree of re-epithelialization on day 4 by 14% compared with the control solution (95% confidence inter-val (CI) 6.8–20%, p = 0.00051) and was not inferior (p < 0.0001) to the control solution on day 10 (0.3%, 95% CI –1.3–1.9%). Median bacterial counts were lower with stabilized hypochlorous acid compared with control and were further reduced after irrigation and treatment of both groups on day 4, but remained lower in the stabilized hypochlorous acid group compared with the control group. This study demonstrat-es immediate and durable antimicrobial action and a bene ficial effect on acute wound healing after irrigation and treatment with a stabilized hypochlorous acid formulation.
Originalsprog | Engelsk |
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Artikelnummer | adv00727 |
Tidsskrift | Acta Dermato-Venereologica |
Vol/bind | 102 |
Antal sider | 7 |
ISSN | 0001-5555 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:The authors are grateful to all the participants, the excellent study nurses Stine Ingvertsen and Susan Bermark, and Lasse Anders-son Kvich at Costerton Biofilm Center for the microbiological analyses. KKM is medical advisor and GG is employee of SoftOx Solutions AS. Grants were given by SoftOx Solutions AS to the institution for the conduct of the study.
Publisher Copyright:
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