Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2

Alicia Lundby, Thomas Jespersen, Nicole Schmitt, Morten Grunnet, Søren-Peter Olesen, Jonathan M Cordeiro, Kirstine Calloe

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

43 Citationer (Scopus)

Abstract

The compound NS5806 increases the transient outward current (I(to)) in canine ventricular cardiomyocytes and slows current decay. In human and canine ventricle, I(to) is thought to be mediated by K(V)4.3 and various ancillary proteins, yet, the exact subunit composition of I(to) channels is still debated. Here we characterize the effect of NS5806 on heterologously expressed putative I(to) channel subunits and other potassium channels.
OriginalsprogEngelsk
TidsskriftBritish Journal of Pharmacology
Vol/bind160
Udgave nummer8
Sider (fra-til)2028-44
Antal sider17
ISSN0007-1188
DOI
StatusUdgivet - aug. 2010

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