Effect of tumor necrosis factor-alpha infusion on the incretin effect in healthy volunteers

Signe Tellerup Nielsen; Louise Lehrskov-Schmidt; Rikke Krogh-Madsen; Thomas Solomon; Lars Lehrskov-Schmidt; Jens Juul Holst; Kirsten Møller

doi:10.1002/dmrr.2441

Effect of tumor necrosis factor-alpha infusion on the incretin effect in healthy volunteers

Signe Tellerup Nielsen, Louise Lehrskov-Schmidt, Rikke Krogh-Madsen, Thomas Solomon, Lars Lehrskov-Schmidt, Jens Juul Holst, Kirsten Møller

Ph.d.-studienævnet for Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

21 Citationer (Scopus)

Abstract

Type 2 diabetes mellitus (T2DM) is associated with peripheral insulin resistance, impaired incretin effect, and increased plasma levels of tumor necrosis factor-alpha (TNF-α). Whereas TNF-α infusion at a dose that induces systemic inflammation in healthy volunteers has been demonstrated to induce peripheral insulin resistance, the influence of this cytokine on the incretin effect is unknown.

Originalsprog	Engelsk
Tidsskrift	Diabetes - Metabolism: Research and Reviews (Online)
Vol/bind	29
Udgave nummer	8
Sider (fra-til)	655-663
Antal sider	9
ISSN	1520-7560
DOI	https://doi.org/10.1002/dmrr.2441
Status	Udgivet - 31 jul. 2013

Adgang til dokumentet

10.1002/dmrr.2441

Citationsformater

Effect of tumor necrosis factor-alpha infusion on the incretin effect in healthy volunteers. / Nielsen, Signe Tellerup; Lehrskov-Schmidt, Louise; Krogh-Madsen, Rikke; Solomon, Thomas; Lehrskov-Schmidt, Lars; Holst, Jens Juul; Møller, Kirsten.

I: Diabetes - Metabolism: Research and Reviews (Online), Bind 29, Nr. 8, 31.07.2013, s. 655-663.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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AU - Solomon, Thomas

AU - Lehrskov-Schmidt, Lars

AU - Holst, Jens Juul

AU - Møller, Kirsten

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AB - Type 2 diabetes mellitus (T2DM) is associated with peripheral insulin resistance, impaired incretin effect, and increased plasma levels of tumor necrosis factor-alpha (TNF-α). Whereas TNF-α infusion at a dose that induces systemic inflammation in healthy volunteers has been demonstrated to induce peripheral insulin resistance, the influence of this cytokine on the incretin effect is unknown.

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