Effect of volume expansion on systemic hemodynamics and central and arterial blood volume in cirrhosis

S Møller; F Bendtsen; Jens Henrik Sahl Henriksen

Effect of volume expansion on systemic hemodynamics and central and arterial blood volume in cirrhosis

S Møller, F Bendtsen, Jens Henrik Sahl Henriksen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

133 Citationer (Scopus)

Abstract

Udgivelsesdato: 1995-Dec

Originalsprog	Engelsk
Tidsskrift	Gastroenterology
Vol/bind	109
Udgave nummer	6
Sider (fra-til)	1917-25
Antal sider	8
ISSN	0016-5085
Status	Udgivet - 1995

Bibliografisk note

Keywords: Adult; Aged; Arteries; Blood Pressure; Blood Volume; Cardiac Output; Hemodynamics; Humans; Liver; Liver Cirrhosis; Middle Aged; Plasma Volume; Vascular Resistance; Vasodilation

Citationsformater

@article{56572ae02b7711df8ed1000ea68e967b,

title = "Effect of volume expansion on systemic hemodynamics and central and arterial blood volume in cirrhosis",

abstract = "BACKGROUND & AIMS: Systemic vasodilatation in cirrhosis may lead to hemodynamic alterations with reduced effective blood volume and decreased arterial blood pressure. This study investigates the response of acute volume expansion on hemodynamics and regional blood volumes in patients with cirrhosis and in controls. METHODS: Thirty-nine patients with cirrhosis (12 patients with Child-Turcotte class A, 14 with class B, and 13 with class C) and 6 controls were studied. During hepatic vein catheterization, cardiac output, systemic vascular resistance, central and arterial blood volume, noncentral blood volume, and arterial pressure were determined before and during a volume expansion induced by infusion of a hyperosmotic galactose solution. RESULTS: During volume expansion, the central and arterial blood volume increased significantly in patients with class A and controls, whereas no significant change was found in patients with either class B or class C. Conversely, the noncentral blood volume increased in patients with class B and C. In both patients and controls, the cardiac output increased and the systemic vascular resistance decreased, whereas the mean arterial blood pressure did not change significantly. CONCLUSIONS: Only in mild cirrhosis is the effective blood volume able to increase in response to volume expansion. Our results are consistent with the peripheral vasodilatation hypothesis and the circulatory hyporeactivity occurring in advanced cirrhosis.",

author = "S M{\o}ller and F Bendtsen and Henriksen, {Jens Henrik Sahl}",

note = "Keywords: Adult; Aged; Arteries; Blood Pressure; Blood Volume; Cardiac Output; Hemodynamics; Humans; Liver; Liver Cirrhosis; Middle Aged; Plasma Volume; Vascular Resistance; Vasodilation",

year = "1995",

language = "English",

volume = "109",

pages = "1917--25",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Effect of volume expansion on systemic hemodynamics and central and arterial blood volume in cirrhosis

AU - Møller, S

AU - Bendtsen, F

AU - Henriksen, Jens Henrik Sahl

N1 - Keywords: Adult; Aged; Arteries; Blood Pressure; Blood Volume; Cardiac Output; Hemodynamics; Humans; Liver; Liver Cirrhosis; Middle Aged; Plasma Volume; Vascular Resistance; Vasodilation

PY - 1995

Y1 - 1995

N2 - BACKGROUND & AIMS: Systemic vasodilatation in cirrhosis may lead to hemodynamic alterations with reduced effective blood volume and decreased arterial blood pressure. This study investigates the response of acute volume expansion on hemodynamics and regional blood volumes in patients with cirrhosis and in controls. METHODS: Thirty-nine patients with cirrhosis (12 patients with Child-Turcotte class A, 14 with class B, and 13 with class C) and 6 controls were studied. During hepatic vein catheterization, cardiac output, systemic vascular resistance, central and arterial blood volume, noncentral blood volume, and arterial pressure were determined before and during a volume expansion induced by infusion of a hyperosmotic galactose solution. RESULTS: During volume expansion, the central and arterial blood volume increased significantly in patients with class A and controls, whereas no significant change was found in patients with either class B or class C. Conversely, the noncentral blood volume increased in patients with class B and C. In both patients and controls, the cardiac output increased and the systemic vascular resistance decreased, whereas the mean arterial blood pressure did not change significantly. CONCLUSIONS: Only in mild cirrhosis is the effective blood volume able to increase in response to volume expansion. Our results are consistent with the peripheral vasodilatation hypothesis and the circulatory hyporeactivity occurring in advanced cirrhosis.

AB - BACKGROUND & AIMS: Systemic vasodilatation in cirrhosis may lead to hemodynamic alterations with reduced effective blood volume and decreased arterial blood pressure. This study investigates the response of acute volume expansion on hemodynamics and regional blood volumes in patients with cirrhosis and in controls. METHODS: Thirty-nine patients with cirrhosis (12 patients with Child-Turcotte class A, 14 with class B, and 13 with class C) and 6 controls were studied. During hepatic vein catheterization, cardiac output, systemic vascular resistance, central and arterial blood volume, noncentral blood volume, and arterial pressure were determined before and during a volume expansion induced by infusion of a hyperosmotic galactose solution. RESULTS: During volume expansion, the central and arterial blood volume increased significantly in patients with class A and controls, whereas no significant change was found in patients with either class B or class C. Conversely, the noncentral blood volume increased in patients with class B and C. In both patients and controls, the cardiac output increased and the systemic vascular resistance decreased, whereas the mean arterial blood pressure did not change significantly. CONCLUSIONS: Only in mild cirrhosis is the effective blood volume able to increase in response to volume expansion. Our results are consistent with the peripheral vasodilatation hypothesis and the circulatory hyporeactivity occurring in advanced cirrhosis.

M3 - Journal article

C2 - 7498657

SN - 0016-5085

VL - 109

SP - 1917

EP - 1925

JO - Gastroenterology

JF - Gastroenterology

IS - 6

ER -