Effector and regulatory T cells in patients with acute optic neuritis

Anna Tsakiri, Erik Kjærsgaard, Nikolaos Grigoriadis, Inge Marie Svane, Jette L Frederiksen

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    Abstract

    Optic neuritis (ON) is an autoimmune acute demyelinating disease of the optic nerve and may occur in patients with confirmed multiple sclerosis (MS) or as a clinically isolated syndrome. T lymphocytes play a central role in the pathogenesis of MS. The phenotype of different T cell subsets is usually characterized by the expression of distinct cell surface receptors such as CD45RA, CD45RO, CCR7, CD27 and CD28. The aim of this study was to characterize the phenotype of distinct subsets of CD4 and CD8 T cells in patients with isolated ON.
    OriginalsprogEngelsk
    TidsskriftNeuroimmunomodulation
    Vol/bind19
    Udgave nummer2
    Sider (fra-til)111-20
    Antal sider10
    ISSN1021-7401
    DOI
    StatusUdgivet - 2012

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