Effects of a 12-week supervised resistance training program, combined with home-based physical activity, on physical fitness and quality of life in female breast cancer survivors: the EFICAN randomized controlled trial

Alberto Soriano-Maldonado; David M. Díez-Fernández; Alba Esteban-Simón; Manuel A. Rodríguez-Pérez; Eva Artés-Rodríguez; Miguel A. Casimiro-Artés; Herminia Moreno-Martos; Antonio Toro-de-Federico; Nur Hachem-Salas; Cecilie Bartholdy; Marius Henriksen; Antonio J. Casimiro-Andújar

doi:10.1007/s11764-022-01192-1

Effects of a 12-week supervised resistance training program, combined with home-based physical activity, on physical fitness and quality of life in female breast cancer survivors: the EFICAN randomized controlled trial

Alberto Soriano-Maldonado^*, David M. Díez-Fernández, Alba Esteban-Simón, Manuel A. Rodríguez-Pérez, Eva Artés-Rodríguez, Miguel A. Casimiro-Artés, Herminia Moreno-Martos, Antonio Toro-de-Federico, Nur Hachem-Salas, Cecilie Bartholdy, Marius Henriksen, Antonio J. Casimiro-Andújar

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

1 Citationer (Scopus)

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Abstract

Purpose: This study assessed the effects of 12-week supervised resistance training combined with home-based physical activity on physical fitness, cancer-related fatigue, depressive symptoms, health-related quality of life (HRQoL), and life satisfaction in female breast cancer survivors. Methods: A parallel-group, outcome assessor-blinded, randomized controlled trial included 60 female breast cancer survivors who had completed their core treatments within the previous 10 years. Through computer-generated simple randomization, participants were assigned to resistance training (RTG; two sessions/week for 12 weeks plus instructions to undertake ≥ 10,000 steps/d) or control (CG; ≥ 10,000 steps/d only). Outcomes were evaluated at baseline and week 12. Muscular strength was assessed with electromechanical dynamometry. A standardized full-body muscular strength score was the primary outcome. Secondary outcomes included cardiorespiratory fitness, shoulder mobility, cancer-related fatigue, depressive symptoms, HRQoL, and life satisfaction. Results: Thirty-two participants were assigned to RTG (29 achieved ≥ 75% attendance) and 28 to CG (all completed the trial). Intention-to-treat analyses revealed that the standardized full-body muscular strength score increased significantly in the RTG compared to the CG (0.718; 95% CI 0.361–1.074, P < 0.001, Cohen's d = 1.04). This increase was consistent for the standardized scores of upper-body (0.727; 95% CI 0.294–1.160, P = 0.001, d = 0.87) and lower-body (0.709; 95% CI 0.324–1.094, P = 0.001, d = 0.96) strength. There was no effect on cardiorespiratory fitness, shoulder flexion, cancer-related fatigue, depressive symptoms, HRQoL, or life satisfaction. The sensitivity analyses confirmed these results. Conclusion: and implication for cancer survivors. In female breast cancer survivors who had completed their core treatments within the past 10 years, adding two weekly sessions of supervised resistance training to a prescription of home-based physical activity for 12 weeks produced a large increase in upper-, lower-, and full-body muscular strength, while other fitness components and patient-reported outcomes did not improve. Trial registration number. ISRCTN14601208.

Originalsprog	Engelsk
Tidsskrift	Journal of Cancer Survivorship
Vol/bind	17
Sider (fra-til)	1371–1385
Antal sider	15
ISSN	1932-2259
DOI	https://doi.org/10.1007/s11764-022-01192-1
Status	Udgivet - 2023

Bibliografisk note

Funding Information:
Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was funded by the Patronato Municipal de Deportes, Ayuntamiento de Almería, and by the UAL Transfiere Research Program (reference number TRFE-SI-2019/004). DD-F was funded by a scholarship from the UAL Transfiere Research Program of the University of Almería (reference number TRFE-BT-2019/002) and is currently funded by the Ministry of Science, Innovation and Universities of the government of Spain (grant number FPU19/04608). Alberto Soriano-Maldonado was supported by the Spanish Ministry of Science, Innovation and Universities (ref. RTI2018–093302-A-I00). The funders did not have any role in the study design, data collection and analyses, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2022, The Author(s).

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Citationsformater

Soriano-Maldonado, A., Díez-Fernández, D. M., Esteban-Simón, A., Rodríguez-Pérez, M. A., Artés-Rodríguez, E., Casimiro-Artés, M. A., Moreno-Martos, H., Toro-de-Federico, A., Hachem-Salas, N., Bartholdy, C., Henriksen, M., & Casimiro-Andújar, A. J. (2023). Effects of a 12-week supervised resistance training program, combined with home-based physical activity, on physical fitness and quality of life in female breast cancer survivors: the EFICAN randomized controlled trial. Journal of Cancer Survivorship, 17, 1371–1385. https://doi.org/10.1007/s11764-022-01192-1

Effects of a 12-week supervised resistance training program, combined with home-based physical activity, on physical fitness and quality of life in female breast cancer survivors : the EFICAN randomized controlled trial. / Soriano-Maldonado, Alberto; Díez-Fernández, David M.; Esteban-Simón, Alba; Rodríguez-Pérez, Manuel A.; Artés-Rodríguez, Eva; Casimiro-Artés, Miguel A.; Moreno-Martos, Herminia; Toro-de-Federico, Antonio; Hachem-Salas, Nur; Bartholdy, Cecilie; Henriksen, Marius; Casimiro-Andújar, Antonio J.

I: Journal of Cancer Survivorship, Bind 17, 2023, s. 1371–1385.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Soriano-Maldonado, A, Díez-Fernández, DM, Esteban-Simón, A, Rodríguez-Pérez, MA, Artés-Rodríguez, E, Casimiro-Artés, MA, Moreno-Martos, H, Toro-de-Federico, A, Hachem-Salas, N, Bartholdy, C, Henriksen, M & Casimiro-Andújar, AJ 2023, 'Effects of a 12-week supervised resistance training program, combined with home-based physical activity, on physical fitness and quality of life in female breast cancer survivors: the EFICAN randomized controlled trial', Journal of Cancer Survivorship, bind 17, s. 1371–1385. https://doi.org/10.1007/s11764-022-01192-1

Soriano-Maldonado A, Díez-Fernández DM, Esteban-Simón A, Rodríguez-Pérez MA, Artés-Rodríguez E, Casimiro-Artés MA et al. Effects of a 12-week supervised resistance training program, combined with home-based physical activity, on physical fitness and quality of life in female breast cancer survivors: the EFICAN randomized controlled trial. Journal of Cancer Survivorship. 2023;17:1371–1385. https://doi.org/10.1007/s11764-022-01192-1

Soriano-Maldonado, Alberto ; Díez-Fernández, David M. ; Esteban-Simón, Alba ; Rodríguez-Pérez, Manuel A. ; Artés-Rodríguez, Eva ; Casimiro-Artés, Miguel A. ; Moreno-Martos, Herminia ; Toro-de-Federico, Antonio ; Hachem-Salas, Nur ; Bartholdy, Cecilie ; Henriksen, Marius ; Casimiro-Andújar, Antonio J. / Effects of a 12-week supervised resistance training program, combined with home-based physical activity, on physical fitness and quality of life in female breast cancer survivors : the EFICAN randomized controlled trial. I: Journal of Cancer Survivorship. 2023 ; Bind 17. s. 1371–1385.

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title = "Effects of a 12-week supervised resistance training program, combined with home-based physical activity, on physical fitness and quality of life in female breast cancer survivors: the EFICAN randomized controlled trial",

abstract = "Purpose: This study assessed the effects of 12-week supervised resistance training combined with home-based physical activity on physical fitness, cancer-related fatigue, depressive symptoms, health-related quality of life (HRQoL), and life satisfaction in female breast cancer survivors. Methods: A parallel-group, outcome assessor-blinded, randomized controlled trial included 60 female breast cancer survivors who had completed their core treatments within the previous 10 years. Through computer-generated simple randomization, participants were assigned to resistance training (RTG; two sessions/week for 12 weeks plus instructions to undertake ≥ 10,000 steps/d) or control (CG; ≥ 10,000 steps/d only). Outcomes were evaluated at baseline and week 12. Muscular strength was assessed with electromechanical dynamometry. A standardized full-body muscular strength score was the primary outcome. Secondary outcomes included cardiorespiratory fitness, shoulder mobility, cancer-related fatigue, depressive symptoms, HRQoL, and life satisfaction. Results: Thirty-two participants were assigned to RTG (29 achieved ≥ 75% attendance) and 28 to CG (all completed the trial). Intention-to-treat analyses revealed that the standardized full-body muscular strength score increased significantly in the RTG compared to the CG (0.718; 95% CI 0.361–1.074, P < 0.001, Cohen's d = 1.04). This increase was consistent for the standardized scores of upper-body (0.727; 95% CI 0.294–1.160, P = 0.001, d = 0.87) and lower-body (0.709; 95% CI 0.324–1.094, P = 0.001, d = 0.96) strength. There was no effect on cardiorespiratory fitness, shoulder flexion, cancer-related fatigue, depressive symptoms, HRQoL, or life satisfaction. The sensitivity analyses confirmed these results. Conclusion: and implication for cancer survivors. In female breast cancer survivors who had completed their core treatments within the past 10 years, adding two weekly sessions of supervised resistance training to a prescription of home-based physical activity for 12 weeks produced a large increase in upper-, lower-, and full-body muscular strength, while other fitness components and patient-reported outcomes did not improve. Trial registration number. ISRCTN14601208.",

keywords = "Breast cancer, Cancer-related fatigue, Health-related quality of life, Muscular strength, Resistance training",

author = "Alberto Soriano-Maldonado and D{\'i}ez-Fern{\'a}ndez, {David M.} and Alba Esteban-Sim{\'o}n and Rodr{\'i}guez-P{\'e}rez, {Manuel A.} and Eva Art{\'e}s-Rodr{\'i}guez and Casimiro-Art{\'e}s, {Miguel A.} and Herminia Moreno-Martos and Antonio Toro-de-Federico and Nur Hachem-Salas and Cecilie Bartholdy and Marius Henriksen and Casimiro-And{\'u}jar, {Antonio J.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2023",

doi = "10.1007/s11764-022-01192-1",

language = "English",

volume = "17",

pages = "1371–1385",

journal = "Journal of Cancer Survivorship",

issn = "1932-2259",

publisher = "Springer",

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TY - JOUR

T1 - Effects of a 12-week supervised resistance training program, combined with home-based physical activity, on physical fitness and quality of life in female breast cancer survivors

T2 - the EFICAN randomized controlled trial

AU - Soriano-Maldonado, Alberto

AU - Díez-Fernández, David M.

AU - Esteban-Simón, Alba

AU - Rodríguez-Pérez, Manuel A.

AU - Artés-Rodríguez, Eva

AU - Casimiro-Artés, Miguel A.

AU - Moreno-Martos, Herminia

AU - Toro-de-Federico, Antonio

AU - Hachem-Salas, Nur

AU - Bartholdy, Cecilie

AU - Henriksen, Marius

AU - Casimiro-Andújar, Antonio J.

PY - 2023

Y1 - 2023

N2 - Purpose: This study assessed the effects of 12-week supervised resistance training combined with home-based physical activity on physical fitness, cancer-related fatigue, depressive symptoms, health-related quality of life (HRQoL), and life satisfaction in female breast cancer survivors. Methods: A parallel-group, outcome assessor-blinded, randomized controlled trial included 60 female breast cancer survivors who had completed their core treatments within the previous 10 years. Through computer-generated simple randomization, participants were assigned to resistance training (RTG; two sessions/week for 12 weeks plus instructions to undertake ≥ 10,000 steps/d) or control (CG; ≥ 10,000 steps/d only). Outcomes were evaluated at baseline and week 12. Muscular strength was assessed with electromechanical dynamometry. A standardized full-body muscular strength score was the primary outcome. Secondary outcomes included cardiorespiratory fitness, shoulder mobility, cancer-related fatigue, depressive symptoms, HRQoL, and life satisfaction. Results: Thirty-two participants were assigned to RTG (29 achieved ≥ 75% attendance) and 28 to CG (all completed the trial). Intention-to-treat analyses revealed that the standardized full-body muscular strength score increased significantly in the RTG compared to the CG (0.718; 95% CI 0.361–1.074, P < 0.001, Cohen's d = 1.04). This increase was consistent for the standardized scores of upper-body (0.727; 95% CI 0.294–1.160, P = 0.001, d = 0.87) and lower-body (0.709; 95% CI 0.324–1.094, P = 0.001, d = 0.96) strength. There was no effect on cardiorespiratory fitness, shoulder flexion, cancer-related fatigue, depressive symptoms, HRQoL, or life satisfaction. The sensitivity analyses confirmed these results. Conclusion: and implication for cancer survivors. In female breast cancer survivors who had completed their core treatments within the past 10 years, adding two weekly sessions of supervised resistance training to a prescription of home-based physical activity for 12 weeks produced a large increase in upper-, lower-, and full-body muscular strength, while other fitness components and patient-reported outcomes did not improve. Trial registration number. ISRCTN14601208.

AB - Purpose: This study assessed the effects of 12-week supervised resistance training combined with home-based physical activity on physical fitness, cancer-related fatigue, depressive symptoms, health-related quality of life (HRQoL), and life satisfaction in female breast cancer survivors. Methods: A parallel-group, outcome assessor-blinded, randomized controlled trial included 60 female breast cancer survivors who had completed their core treatments within the previous 10 years. Through computer-generated simple randomization, participants were assigned to resistance training (RTG; two sessions/week for 12 weeks plus instructions to undertake ≥ 10,000 steps/d) or control (CG; ≥ 10,000 steps/d only). Outcomes were evaluated at baseline and week 12. Muscular strength was assessed with electromechanical dynamometry. A standardized full-body muscular strength score was the primary outcome. Secondary outcomes included cardiorespiratory fitness, shoulder mobility, cancer-related fatigue, depressive symptoms, HRQoL, and life satisfaction. Results: Thirty-two participants were assigned to RTG (29 achieved ≥ 75% attendance) and 28 to CG (all completed the trial). Intention-to-treat analyses revealed that the standardized full-body muscular strength score increased significantly in the RTG compared to the CG (0.718; 95% CI 0.361–1.074, P < 0.001, Cohen's d = 1.04). This increase was consistent for the standardized scores of upper-body (0.727; 95% CI 0.294–1.160, P = 0.001, d = 0.87) and lower-body (0.709; 95% CI 0.324–1.094, P = 0.001, d = 0.96) strength. There was no effect on cardiorespiratory fitness, shoulder flexion, cancer-related fatigue, depressive symptoms, HRQoL, or life satisfaction. The sensitivity analyses confirmed these results. Conclusion: and implication for cancer survivors. In female breast cancer survivors who had completed their core treatments within the past 10 years, adding two weekly sessions of supervised resistance training to a prescription of home-based physical activity for 12 weeks produced a large increase in upper-, lower-, and full-body muscular strength, while other fitness components and patient-reported outcomes did not improve. Trial registration number. ISRCTN14601208.

KW - Breast cancer

KW - Cancer-related fatigue

KW - Health-related quality of life

KW - Muscular strength

KW - Resistance training

U2 - 10.1007/s11764-022-01192-1

DO - 10.1007/s11764-022-01192-1

M3 - Journal article

C2 - 35314958

AN - SCOPUS:85126777054

VL - 17

SP - 1371

EP - 1385

JO - Journal of Cancer Survivorship

JF - Journal of Cancer Survivorship

SN - 1932-2259

ER -