Abstract
The aim was to validate possible vasodilating effects of a Ginkgo biloba extract with a secondary aim of finding a pharmacodynamic signal relating to the active component of these extracts. We studied the effect of G. biloba extract on forearm haemodynamics in 16 healthy subjects (nine females, seven males) with a median age of 32 years (range: 21-47). The study was conducted as a randomized, double-blinded cross-over design using oral treatment with G. biloba extract (Gibidyl Forte(R) t.i.d. or placebo for 6 weeks. Forearm blood flow and venous capacity were measured by strain-gauge plethysmography. Blood pressure was measured by standard sphygmomanometry, and forearm vascular resistance (FVR) was derived. Measurements were made at baseline and after 3, 6, 9 and 12 weeks of treatment. Forearm blood flow was significantly higher during active treatment after 3 and 6 weeks as compared with placebo treatment for 3 and 6 weeks (P
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Clinical Physiology and Functional Imaging |
| Vol/bind | 22 |
| Udgave nummer | 6 |
| Sider (fra-til) | 375-8 |
| Antal sider | 4 |
| ISSN | 1475-0961 |
| Status | Udgivet - 1 nov. 2002 |