Effects of body mass index and age on N-terminal pro brain natriuretic peptide are associated with glomerular filtration rate in chronic heart failure patients.

Morten Schou; Finn Gustafsson; Caroline N Kistorp; Pernille Corell; Andreas Kjaer; Per R Hildebrandt

doi:10.1373/clinchem.2006.084426

Effects of body mass index and age on N-terminal pro brain natriuretic peptide are associated with glomerular filtration rate in chronic heart failure patients.

Morten Schou, Finn Gustafsson, Caroline N Kistorp, Pernille Corell, Andreas Kjaer, Per R Hildebrandt

Biomedicinsk Institut

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

26 Citationer (Scopus)

Abstract

Udgivelsesdato: 2007-Nov

Originalsprog	Engelsk
Tidsskrift	Clinical Chemistry
Vol/bind	53
Udgave nummer	11
Sider (fra-til)	1928-35
Antal sider	7
ISSN	0009-9147
DOI	https://doi.org/10.1373/clinchem.2006.084426
Status	Udgivet - 2007

Bibliografisk note

Keywords: Adult; Age Factors; Aged; Aged, 80 and over; Body Mass Index; Chronic Disease; Female; Glomerular Filtration Rate; Heart Failure; Humans; Linear Models; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments

Adgang til dokumentet

10.1373/clinchem.2006.084426

Biblioteksadgang?

Tjek tilgængelighed hos det Kgl. Bibliotek

Citationsformater

@article{da0b1c50accc11ddb538000ea68e967b,

title = "Effects of body mass index and age on N-terminal pro brain natriuretic peptide are associated with glomerular filtration rate in chronic heart failure patients.",

abstract = "BACKGROUND: Obesity is a state characterized by glomerular hyperfiltration and age-related decreases in glomerular filtration rate (GFR). Body mass index (BMI), age, and GFR are associated with plasma concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) in chronic heart failure (CHF) patients. We hypothesized that the effects of BMI and age on plasma concentrations of NT-proBNP are associated with GFR. METHODS: We obtained clinical data and laboratory test results from 345 CHF patients at the baseline visit in our heart failure clinic and examined the hypothesis using multiple linear regression models. RESULTS: Age (P = 0.0184), BMI (P = 0.0098), hemoglobin (P = 0.0043), heart rhythm (P <0.0001), and left ventricular ejection fraction (P <0.0001) were associated with log(NT-proBNP). After adjustment for GFR estimated by the Cockcroft and Gault equation, the parameter estimates for BMI (P = 0.3807) and age (P = 0.7238) changed markedly and became insignificant. In another model, after adjustment for GFR estimated by the 4-component Modification of Diet in Renal Disease formula (eGFR(MDRD)), the parameter estimates for age (P = 0.0674) changed markedly and became insignificant, but BMI (P = 0.0067) remained significant and unchanged. The eGFR(MDRD) is adjusted for body surface area, which may explain the difference. CONCLUSIONS: In CHF patients, the effect of age on NT-proBNP is associated with estimates for GFR derived from serum creatinine, and the significance of the effects of BMI on NT-proBNP depends on the method by which GFR is estimated.",

author = "Morten Schou and Finn Gustafsson and Kistorp, {Caroline N} and Pernille Corell and Andreas Kjaer and Hildebrandt, {Per R}",

note = "Keywords: Adult; Age Factors; Aged; Aged, 80 and over; Body Mass Index; Chronic Disease; Female; Glomerular Filtration Rate; Heart Failure; Humans; Linear Models; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments",

year = "2007",

doi = "10.1373/clinchem.2006.084426",

language = "English",

volume = "53",

pages = "1928--35",

journal = "Clinical Chemistry",

issn = "0009-9147",

publisher = "American Association for Clinical Chemistry, Inc.",

number = "11",

}

TY - JOUR

T1 - Effects of body mass index and age on N-terminal pro brain natriuretic peptide are associated with glomerular filtration rate in chronic heart failure patients.

AU - Schou, Morten

AU - Gustafsson, Finn

AU - Kistorp, Caroline N

AU - Corell, Pernille

AU - Kjaer, Andreas

AU - Hildebrandt, Per R

N1 - Keywords: Adult; Age Factors; Aged; Aged, 80 and over; Body Mass Index; Chronic Disease; Female; Glomerular Filtration Rate; Heart Failure; Humans; Linear Models; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments

PY - 2007

Y1 - 2007

N2 - BACKGROUND: Obesity is a state characterized by glomerular hyperfiltration and age-related decreases in glomerular filtration rate (GFR). Body mass index (BMI), age, and GFR are associated with plasma concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) in chronic heart failure (CHF) patients. We hypothesized that the effects of BMI and age on plasma concentrations of NT-proBNP are associated with GFR. METHODS: We obtained clinical data and laboratory test results from 345 CHF patients at the baseline visit in our heart failure clinic and examined the hypothesis using multiple linear regression models. RESULTS: Age (P = 0.0184), BMI (P = 0.0098), hemoglobin (P = 0.0043), heart rhythm (P <0.0001), and left ventricular ejection fraction (P <0.0001) were associated with log(NT-proBNP). After adjustment for GFR estimated by the Cockcroft and Gault equation, the parameter estimates for BMI (P = 0.3807) and age (P = 0.7238) changed markedly and became insignificant. In another model, after adjustment for GFR estimated by the 4-component Modification of Diet in Renal Disease formula (eGFR(MDRD)), the parameter estimates for age (P = 0.0674) changed markedly and became insignificant, but BMI (P = 0.0067) remained significant and unchanged. The eGFR(MDRD) is adjusted for body surface area, which may explain the difference. CONCLUSIONS: In CHF patients, the effect of age on NT-proBNP is associated with estimates for GFR derived from serum creatinine, and the significance of the effects of BMI on NT-proBNP depends on the method by which GFR is estimated.

AB - BACKGROUND: Obesity is a state characterized by glomerular hyperfiltration and age-related decreases in glomerular filtration rate (GFR). Body mass index (BMI), age, and GFR are associated with plasma concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) in chronic heart failure (CHF) patients. We hypothesized that the effects of BMI and age on plasma concentrations of NT-proBNP are associated with GFR. METHODS: We obtained clinical data and laboratory test results from 345 CHF patients at the baseline visit in our heart failure clinic and examined the hypothesis using multiple linear regression models. RESULTS: Age (P = 0.0184), BMI (P = 0.0098), hemoglobin (P = 0.0043), heart rhythm (P <0.0001), and left ventricular ejection fraction (P <0.0001) were associated with log(NT-proBNP). After adjustment for GFR estimated by the Cockcroft and Gault equation, the parameter estimates for BMI (P = 0.3807) and age (P = 0.7238) changed markedly and became insignificant. In another model, after adjustment for GFR estimated by the 4-component Modification of Diet in Renal Disease formula (eGFR(MDRD)), the parameter estimates for age (P = 0.0674) changed markedly and became insignificant, but BMI (P = 0.0067) remained significant and unchanged. The eGFR(MDRD) is adjusted for body surface area, which may explain the difference. CONCLUSIONS: In CHF patients, the effect of age on NT-proBNP is associated with estimates for GFR derived from serum creatinine, and the significance of the effects of BMI on NT-proBNP depends on the method by which GFR is estimated.

U2 - 10.1373/clinchem.2006.084426

DO - 10.1373/clinchem.2006.084426

M3 - Journal article

C2 - 17872942

SN - 0009-9147

VL - 53

SP - 1928

EP - 1935

JO - Clinical Chemistry

JF - Clinical Chemistry

IS - 11

ER -