Effects of buprenorphine on acute pain and inflammation in the adjuvant-induced monoarthritis rat model

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Abstract

Animal modelling of arthritis is often associated with pain and suffering. Severity may be reduced with the use of analgesia which is, however, often withheld due to concerns of introducing a confounding variable. It is therefore important to design and validate pain relief protocols that reduce pain without compromising the scientific objectives. The present study evaluated the effect of buprenorphine analgesia in the immediate post-induction period of an adjuvant-induced monoarthritic rat model. The aim of this study was to extend previous work on refinement of the model by alleviating unnecessary pain
OriginalsprogEngelsk
Artikelnummere11554
TidsskriftHeliyon
Vol/bind8
Udgave nummer11
Antal sider9
ISSN2405-8440
DOI
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
This work was supported by Danish 3R Center (33010-NIFA-14-586).

Funding Information:
The Authors thank Helle Runchel Porsdal, Trine Marie Ahlman Glahder, Daniel Kylmann Hansen and Gerda Majgaard Jensen for their invaluable assistance.

Publisher Copyright:
© 2022

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