Effects of chondroitin sulfate and glucosamine in adult patients with Kaschin-Beck disease

Ya-xu Zhang, Wei Dong, Hui Liu, Flavia Cicuttini, Maximilian de Courten, Jian-bai Yang

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    Abstract

    The purpose is to investigate the effects of chondroitin sulfate and glucosamine on adult patients with Kaschin-Beck disease (KBD). A total of 80 patients, aged over 40 years, were randomized into two groups receiving either 1,600 mg oral mixture of chondroitin sulfate and glucosamine or placebo twice daily for 8 months. Posteroanterior radiographs of bilateral knee in full extension were taken at enrollment and after 8 months. Mean joint-space width of the assigned six points on the tibiofemoral joint compartment was measured by a graduated magnifying lens. The mean joint space decreased significantly in the placebo group (4.3 +/- 1.09 versus 4.1 +/- 1.07 mm, P <0.0001) after 8 months and was unchanged in the experimental group (P = 0.51). There was no statistical significance in the mean joint space between two groups at baseline and follow-up (P = 0.65 and P = 0.84, respectively). But the overall mean change in joint space was significant between the two groups (P <0.0001). Knee joint space of the experimental group narrowed slowly compared to the control group. Therefore, chondroitin sulfate and glucosamine might play a protective role in preserving articular cartilage and provide evidence for therapeutic drugs in adult patients with KBD.
    OriginalsprogEngelsk
    TidsskriftClinical Rheumatology
    Vol/bind29
    Udgave nummer4
    Sider (fra-til)357-62
    Antal sider6
    ISSN0770-3198
    DOI
    StatusUdgivet - 1 apr. 2010

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