Abstract
Mitochondria, the versatile organelles crucial for cellular and organismal viability, play a pivotal role in meeting the energy requirements of cells through the respiratory chain located in the inner mitochondrial membrane, concomitant with the generation of reactive oxygen species (ROS). A wealth of evidence derived from contemporary investigations on reproductive longevity strongly indicates that the aberrant elevation of ROS level constitutes a fundamental factor in hastening the aging process of reproductive systems which are responsible for transmission of DNA to future generations. Constant changes in redox status, with a pro-oxidant shift mainly through the mitochondrial generation of ROS, are linked to the modulation of physiological and pathological pathways in gametes and reproductive tissues. Furthermore, the quantity and quality of mitochondria essential to capacitation and fertilization are increasingly associated with reproductive aging. The article aims to provide current understanding of the contributions of ROS derived from mitochondrial respiration to the process of reproductive aging. Moreover, understanding the impact of mitochondrial dysfunction on both female and male fertility is conducive to finding therapeutic strategies to slow, prevent or reverse the process of gamete aging, and thereby increase reproductive longevity.
Originalsprog | Engelsk |
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Artikelnummer | 1347286 |
Tidsskrift | Frontiers in Cell and Developmental Biology |
Vol/bind | 12 |
Antal sider | 12 |
ISSN | 2296-634X |
DOI | |
Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (Nos. 32272939 and 31830094, and 31902215); Natural Science Foundation of Chongqing, China (No. cstc2021jcyj-cxtt0005); High-level Talents Program of Southwest University (SWURC2021001); and China Agriculture Research System of MOF and MARA (No. CARS-18-ZJ0102).
Publisher Copyright:
Copyright © 2024 Song, Xiao, Zhang, Wang, Kouis, Rasmussen and Dai.