Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats

K Mangano; N Y Sardesai; C Quattrocchi; E Mazzon; S Cuzzocrea; K Bendtzen; P L Meroni; J J Kim; F Nicoletti

doi:10.1038/bjp.2008.315

Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats

K Mangano, N Y Sardesai, C Quattrocchi, E Mazzon, S Cuzzocrea, K Bendtzen, P L Meroni, J J Kim, F Nicoletti

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

9 Citationer (Scopus)

Abstract

VGX-1027 is a novel, low molecular weight, immunomodulatory compound that has shown efficacy against a variety of immuno-inflammatory disease models in animals including autoimmune diabetes in NOD mice, collagen-induced arthritis and chemically induced inflammatory colitis. Here, we have studied the effects of VGX-1027 on the development of endotoxin-induced uveitis (EIU) in male Lewis rats, as a model of inflammatory ocular diseases in humans.

Originalsprog	Engelsk
Tidsskrift	British Journal of Pharmacology
Vol/bind	155
Udgave nummer	5
Sider (fra-til)	722-30
Antal sider	9
ISSN	0007-1188
DOI	https://doi.org/10.1038/bjp.2008.315
Status	Udgivet - 1 nov. 2008

Adgang til dokumentet

10.1038/bjp.2008.315

Citationsformater

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AU - Mazzon, E

AU - Cuzzocrea, S

AU - Bendtzen, K

AU - Meroni, P L

AU - Kim, J J

AU - Nicoletti, F

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AB - VGX-1027 is a novel, low molecular weight, immunomodulatory compound that has shown efficacy against a variety of immuno-inflammatory disease models in animals including autoimmune diabetes in NOD mice, collagen-induced arthritis and chemically induced inflammatory colitis. Here, we have studied the effects of VGX-1027 on the development of endotoxin-induced uveitis (EIU) in male Lewis rats, as a model of inflammatory ocular diseases in humans.

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