Elevated ACE activity is not associated with asthma, COPD, and COPD co-morbidity

Julie Lee; Borge G. Nordestgaard; Morten Dahl

doi:10.1016/j.rmed.2009.04.003

Elevated ACE activity is not associated with asthma, COPD, and COPD co-morbidity

Julie Lee, Borge G. Nordestgaard, Morten Dahl

IKM

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

17 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Sep

Originalsprog	Engelsk
Tidsskrift	Respiratory Medicine
Vol/bind	103
Udgave nummer	9
Sider (fra-til)	1286-1292
ISSN	0954-6111
DOI	https://doi.org/10.1016/j.rmed.2009.04.003
Status	Udgivet - 2009

Adgang til dokumentet

10.1016/j.rmed.2009.04.003

Citationsformater

@article{2b3bdcd0835011df928f000ea68e967b,

title = "Elevated ACE activity is not associated with asthma, COPD, and COPD co-morbidity",

abstract = "The angiotensin-converting enzyme (ACE) gene is a potential candidate gene for risk of asthma, COPD, and COPD co-morbidity. In 9034 Danish adults, we determined whether individuals homozygous or heterozygous for the ACE D allele are at greater risk of asthma, COPD, or COPD co-morbidity compared with ACE II homozygous individuals. In the general population, serum ACE activity increased with the number of D alleles (Kruskal-Wallis ANOVA: II vs. ID, p<0.001; ID vs. DD, p<0.001); however, this did not translate into altered risk of asthma or COPD. In the general population, the odds ratio (95% confidence interval) for asthma was 1.2 (0.9-1.4) for ID individuals and 1.2 (0.9-1.5) for DD individuals compared with II individuals. In the general population, the odds ratio for COPD was 0.9 (0.8-1.1) for ID individuals and 1.0 (0.8-1.2) for DD individuals compared with II individuals. Among patients with COPD, the odds ratio for ischemic heart disease was 1.1 (0.8-1.6) for ID individuals and 1.2 (0.8-1.7) for DD individuals compared with II individuals; corresponding odds ratios for hypertension were 1.1 (0.7-1.5) and 0.8 (0.5-1.2), and for low physical activity 0.9 (0.5-1.4) and 0.7 (0.4-1.2). The results were similar upon adjustment for sex, age, smoking status, body mass index, total cholesterol, and ACE inhibitor/angiotensin II type 1 receptor blocker use. These data suggest that lifelong genetically elevated ACE activity is not a major risk factor for asthma or COPD, or for ischemic heart disease, hypertension, and low physical activity in COPD patients.",

keywords = "Chronic obstructive pulmonary disease, Ischemic heart disease, Hypertension, Physical activity, Angiotensin-converting enzyme, Asthma",

author = "Julie Lee and Nordestgaard, {Borge G.} and Morten Dahl",

year = "2009",

doi = "10.1016/j.rmed.2009.04.003",

language = "English",

volume = "103",

pages = "1286--1292",

journal = "Respiratory Medicine",

issn = "0954-6111",

publisher = "Elsevier",

number = "9",

}

TY - JOUR

T1 - Elevated ACE activity is not associated with asthma, COPD, and COPD co-morbidity

AU - Lee, Julie

AU - Nordestgaard, Borge G.

AU - Dahl, Morten

PY - 2009

Y1 - 2009

N2 - The angiotensin-converting enzyme (ACE) gene is a potential candidate gene for risk of asthma, COPD, and COPD co-morbidity. In 9034 Danish adults, we determined whether individuals homozygous or heterozygous for the ACE D allele are at greater risk of asthma, COPD, or COPD co-morbidity compared with ACE II homozygous individuals. In the general population, serum ACE activity increased with the number of D alleles (Kruskal-Wallis ANOVA: II vs. ID, p<0.001; ID vs. DD, p<0.001); however, this did not translate into altered risk of asthma or COPD. In the general population, the odds ratio (95% confidence interval) for asthma was 1.2 (0.9-1.4) for ID individuals and 1.2 (0.9-1.5) for DD individuals compared with II individuals. In the general population, the odds ratio for COPD was 0.9 (0.8-1.1) for ID individuals and 1.0 (0.8-1.2) for DD individuals compared with II individuals. Among patients with COPD, the odds ratio for ischemic heart disease was 1.1 (0.8-1.6) for ID individuals and 1.2 (0.8-1.7) for DD individuals compared with II individuals; corresponding odds ratios for hypertension were 1.1 (0.7-1.5) and 0.8 (0.5-1.2), and for low physical activity 0.9 (0.5-1.4) and 0.7 (0.4-1.2). The results were similar upon adjustment for sex, age, smoking status, body mass index, total cholesterol, and ACE inhibitor/angiotensin II type 1 receptor blocker use. These data suggest that lifelong genetically elevated ACE activity is not a major risk factor for asthma or COPD, or for ischemic heart disease, hypertension, and low physical activity in COPD patients.

AB - The angiotensin-converting enzyme (ACE) gene is a potential candidate gene for risk of asthma, COPD, and COPD co-morbidity. In 9034 Danish adults, we determined whether individuals homozygous or heterozygous for the ACE D allele are at greater risk of asthma, COPD, or COPD co-morbidity compared with ACE II homozygous individuals. In the general population, serum ACE activity increased with the number of D alleles (Kruskal-Wallis ANOVA: II vs. ID, p<0.001; ID vs. DD, p<0.001); however, this did not translate into altered risk of asthma or COPD. In the general population, the odds ratio (95% confidence interval) for asthma was 1.2 (0.9-1.4) for ID individuals and 1.2 (0.9-1.5) for DD individuals compared with II individuals. In the general population, the odds ratio for COPD was 0.9 (0.8-1.1) for ID individuals and 1.0 (0.8-1.2) for DD individuals compared with II individuals. Among patients with COPD, the odds ratio for ischemic heart disease was 1.1 (0.8-1.6) for ID individuals and 1.2 (0.8-1.7) for DD individuals compared with II individuals; corresponding odds ratios for hypertension were 1.1 (0.7-1.5) and 0.8 (0.5-1.2), and for low physical activity 0.9 (0.5-1.4) and 0.7 (0.4-1.2). The results were similar upon adjustment for sex, age, smoking status, body mass index, total cholesterol, and ACE inhibitor/angiotensin II type 1 receptor blocker use. These data suggest that lifelong genetically elevated ACE activity is not a major risk factor for asthma or COPD, or for ischemic heart disease, hypertension, and low physical activity in COPD patients.

KW - Chronic obstructive pulmonary disease

KW - Ischemic heart disease

KW - Hypertension

KW - Physical activity

KW - Angiotensin-converting enzyme

KW - Asthma

U2 - 10.1016/j.rmed.2009.04.003

DO - 10.1016/j.rmed.2009.04.003

M3 - Journal article

C2 - 19423314

VL - 103

SP - 1286

EP - 1292

JO - Respiratory Medicine

JF - Respiratory Medicine

SN - 0954-6111

IS - 9

ER -