Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon

P B Jeppesen, B Hartmann, J Thulesen, B S Hansen, J J Holst, Steen Seier Poulsen, P B Mortensen

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179 Citationer (Scopus)

Abstract

The glucagon-like peptides (GLP) 1 and 2 are secreted postprandially from L cells located mainly in the ileum. Both hormones prolong intestinal transit and GLP-2 is intestinotrophic in rodents. Patients with a jejunostomy have poor adaptation, rapid gastric and intestinal transit, and impaired postprandial GLP-2 secretion. Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying.
OriginalsprogEngelsk
TidsskriftGut
Vol/bind47
Udgave nummer3
Sider (fra-til)370-6
Antal sider7
ISSN0017-5749
StatusUdgivet - sep. 2000

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