TY - JOUR
T1 - PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training
AU - Blond, Martin Baeek
AU - Schnurr, Theresia Maria
AU - Rasenkilde, Mads
AU - Quist, Jonas Sailing
AU - Gram, Anne Sofie
AU - Reichkendler, Michala Holm
AU - Auerbach, Pernille Landrock
AU - Nordby, Pernille
AU - Skovgaard, Lene Theil
AU - Ribel-Madsen, Rasmus
AU - Justesen, Johann Marie
AU - Kilpelainen, Tuomas Oskari
AU - Ploug, Thorkil
AU - Stallknecht, Bente Merete
AU - Hansen, Torben
PY - 2019
Y1 - 2019
N2 - The Ala allele of PPARG Pro12Ala (rs1801282) is associated with greater improvements to the glucose metabolism in exercise studies, but whether this extends to peripheral insulin sensitivity is unknown. Our objective was to investigate the effect of PPARG Pro12Ala on exercise-induced changes in peripheral insulin sensitivity. A total of 124 (91 Pro homozygotes and 33 Ala carriers) previously physically inactive healthy young men and women with overweight or class 1 obesity who completed a 12 wk aerobic exercise intervention were included in the analysis. All participants underwent a hyperinsulinemic euglycemic clamp before and after the 12 wk intervention. The prescribed exercise frequency was 5-7 days/wk, and the exercise energy expenditure was 2,100 4,200 kcal/wk for men and 1,600 kcal/wk for women. Insulin sensitivity improved significantly in both genotype groups. However, Ala carriers had a 1.13-fold (95% confidence interval 1.01; 1.26, P = 0.032) greater improvement in insulin sensitivity from baseline compared with Pro homozygotes. Our data support that PPARG Pro12Ala modifies the effect of aerobic exercise on peripheral insulin sensitivity.
AB - The Ala allele of PPARG Pro12Ala (rs1801282) is associated with greater improvements to the glucose metabolism in exercise studies, but whether this extends to peripheral insulin sensitivity is unknown. Our objective was to investigate the effect of PPARG Pro12Ala on exercise-induced changes in peripheral insulin sensitivity. A total of 124 (91 Pro homozygotes and 33 Ala carriers) previously physically inactive healthy young men and women with overweight or class 1 obesity who completed a 12 wk aerobic exercise intervention were included in the analysis. All participants underwent a hyperinsulinemic euglycemic clamp before and after the 12 wk intervention. The prescribed exercise frequency was 5-7 days/wk, and the exercise energy expenditure was 2,100 4,200 kcal/wk for men and 1,600 kcal/wk for women. Insulin sensitivity improved significantly in both genotype groups. However, Ala carriers had a 1.13-fold (95% confidence interval 1.01; 1.26, P = 0.032) greater improvement in insulin sensitivity from baseline compared with Pro homozygotes. Our data support that PPARG Pro12Ala modifies the effect of aerobic exercise on peripheral insulin sensitivity.
KW - exercise
KW - insulin sensitivity
KW - intervention
KW - PPARG
KW - Pro12Ala
U2 - 10.1152/physiolgenomics.00101.2018
DO - 10.1152/physiolgenomics.00101.2018
M3 - Journal article
C2 - 31074700
VL - 51
SP - 254
EP - 260
JO - Physiological Genomics
JF - Physiological Genomics
SN - 1094-8341
IS - 6
ER -