Abstract
A series of spirocyclic carbaldehydes were successfully fluorinated using enamine catalysis, furnishing the corresponding tertiary fluorides in both high yields and enantioselectivities. The fluorinated spirocycles provide a set of novel building blocks interesting from a medicinal chemistry point of view.
Originalsprog | Engelsk |
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Artikelnummer | st-2016-b0535-l |
Tidsskrift | SYNLETT: Accounts and Rapid Communications in Chemical Synthesis |
Vol/bind | 28 |
Udgave nummer | 4 |
Sider (fra-til) | 425-428 |
Antal sider | 4 |
ISSN | 0936-5214 |
DOI | |
Status | Udgivet - 2017 |