Enantioselective Fluorination of Spirocyclic β-Prolinals Using Enamine Catalysis

Kasper Fjelbye*, Mauro Marigo, Rasmus Prætorius Clausen, Karsten Juhl

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

11 Citationer (Scopus)

Abstract

A series of spirocyclic carbaldehydes were successfully fluorinated using enamine catalysis, furnishing the corresponding tertiary fluorides in both high yields and enantioselectivities. The fluorinated spirocycles provide a set of novel building blocks interesting from a medicinal chemistry point of view.

OriginalsprogEngelsk
Artikelnummerst-2016-b0535-l
TidsskriftSYNLETT: Accounts and Rapid Communications in Chemical Synthesis
Vol/bind28
Udgave nummer4
Sider (fra-til)425-428
Antal sider4
ISSN0936-5214
DOI
StatusUdgivet - 2017

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