TY - JOUR
T1 - Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine
AU - Clementson, Sebastian
AU - Jessing, Mikkel
AU - Pedersen, Henrik
AU - Vital, Paulo
AU - Kristensen, Jesper L
PY - 2019/5
Y1 - 2019/5
N2 - Erythrina alkaloids represent a rich source of complex polycyclic, bioactive natural products. In addition to their sedative and hypotensive effect, their curare-like activity and structural framework have made them attractive targets for synthetic and medicinal chemists. (+)-Dihydro-β-erythroidine (DHβE), the most potent nicotine acetylcholine receptor antagonist (nAChR) of the Erythrina family, is synthesized for the first time in 13 steps from commercially available material.
AB - Erythrina alkaloids represent a rich source of complex polycyclic, bioactive natural products. In addition to their sedative and hypotensive effect, their curare-like activity and structural framework have made them attractive targets for synthetic and medicinal chemists. (+)-Dihydro-β-erythroidine (DHβE), the most potent nicotine acetylcholine receptor antagonist (nAChR) of the Erythrina family, is synthesized for the first time in 13 steps from commercially available material.
U2 - 10.1021/jacs.9b04626
DO - 10.1021/jacs.9b04626
M3 - Journal article
C2 - 31122014
VL - 141
SP - 8783
EP - 8786
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 22
ER -