TY - JOUR
T1 - EndoCompass project
T2 - research roadmap for reproductive and developmental endocrinology
AU - Cools, Martine
AU - Krausz, Csilla
AU - Juul, Anders
AU - Macut, Djuro
AU - Andersen, Marianne Skovsager
AU - Andersson, Anna Maria
AU - Andoniadou, Cynthia L.
AU - Ahmed, S. Faisal
AU - Bakker, Julie
AU - Bashamboo, Anu
AU - Behre, Hermann M.
AU - Bonomi, Marco
AU - Busch, Alexander Siegfried
AU - De Roo, Chloë
AU - Dessens, Arianne
AU - Fakhar-I-Adil, Muhammad
AU - Fanelli, Flaminia
AU - Fisher, Alessandra Daphne
AU - Flück, Christa
AU - Gambineri, Alessandra
AU - Giwercman, Aleksander
AU - Gravholt, Claus H.
AU - Hannema, Sabine
AU - Heindryckx, Björn
AU - Hiort, Olaf
AU - Hornig, Nadine C.
AU - Howard, Sasha
AU - Ibáñez, Lourdes
AU - Blomberg Jensen, Martin
AU - Jørgensen, Niels
AU - Livadas, Sarantis
AU - Lucas-Herald, Angela
AU - Mastorakos, George
AU - Meriggiola, Maria Cristina
AU - Ong, Ken
AU - Opalic Palibrk, Milica
AU - Pignatelli, Duarte
AU - Pitteloud, Nelly
AU - Rajpert-De Meyts, Ewa
AU - Rey, Rodolfo
AU - Robeva, Ralitsa
AU - Pozza, Carlotta
AU - Schlatt, Stefan
AU - Spaggiari, Giorgia
AU - Tack, Lloyd
AU - Tena-Sempere, Manuel
AU - Tournaye, Herman
AU - T’Sjoen, Guy
AU - Van Mello, Norah
AU - Vena, Walter
AU - Yildiz, Bulent O.
AU - De Zegher, Francis
N1 - Also published in Horm Res Paediatr (2025):
https://doi.org/10.1159/000549203
Publisher Copyright:
© The Author(s) 2025. Published by Oxford University Press on behalf of European Society of Endocrinology.
PY - 2025
Y1 - 2025
N2 - Background: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project—a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. Methods: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups. Results: Research priorities encompass variations in sex development, hypothalamic–pituitary–gonadal regulation, and female and male reproductive disorders. Key areas include improving diagnostic capacity through (epi)genetic analysis, optimizing hormonal treatments, developing fertility preservation strategies. Special emphasis is placed on establishing pan-European registries, developing novel reproductive technologies, and exploring environmental impacts on reproductive health. Conclusions: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into reproductive and developmental endocrinology pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of the highest potential impact in endocrine health.
AB - Background: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project—a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. Methods: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups. Results: Research priorities encompass variations in sex development, hypothalamic–pituitary–gonadal regulation, and female and male reproductive disorders. Key areas include improving diagnostic capacity through (epi)genetic analysis, optimizing hormonal treatments, developing fertility preservation strategies. Special emphasis is placed on establishing pan-European registries, developing novel reproductive technologies, and exploring environmental impacts on reproductive health. Conclusions: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into reproductive and developmental endocrinology pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of the highest potential impact in endocrine health.
KW - EndoCompass
KW - funding
KW - HPG axis (hypothalamic-pituitary-gonadal
KW - reproduction
KW - roadmap)
U2 - 10.1093/ejendo/lvaf069
DO - 10.1093/ejendo/lvaf069
M3 - Review
C2 - 41104478
AN - SCOPUS:105019113494
SN - 0804-4643
VL - 193
SP - ii97-ii116
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
IS - Supplement_2
ER -