Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | World Journal of Gastroenterology |
| Vol/bind | 15 |
| Udgave nummer | 13 |
| Sider (fra-til) | 1587-93 |
| Antal sider | 7 |
| ISSN | 1007-9327 |
| Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Endosonography; Female; Humans; Lymph Nodes; Male; Middle Aged; Pancreatic Neoplasms; Sensitivity and SpecificityCitationsformater
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I: World Journal of Gastroenterology, Bind 15, Nr. 13, 2009, s. 1587-93.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses: a multicenter study
AU - Giovannini, Marc
AU - Thomas, Botelberge
AU - Erwan, Bories
AU - Christian, Pesenti
AU - Fabrice, Caillol
AU - Benjamin, Esterni
AU - Geneviève, Monges
AU - Paolo, Arcidiacono
AU - Pierre, Deprez
AU - Robert, Yeung
AU - Walter, Schimdt
AU - Hanz, Schrader
AU - Carl, Szymanski
AU - Christoph, Dietrich
AU - Pierre, Eisendrath
AU - Jean-Luc, Van Laethem
AU - Jacques, Devière
AU - Peter, Vilmann
AU - Andrian, Saftoiu
N1 - Keywords: Endosonography; Female; Humans; Lymph Nodes; Male; Middle Aged; Pancreatic Neoplasms; Sensitivity and Specificity
PY - 2009
Y1 - 2009
N2 - AIM: To evaluate the ability of endoscopic ultrasound (EUS) elastography to distinguish benign from malignant pancreatic masses and lymph nodes. METHODS: A multicenter study was conducted and included 222 patients who underwent EUS examination with assessment of a pancreatic mass (n = 121) or lymph node (n = 101). The classification as benign or malignant, based on the real time elastography pattern, was compared with the classification based on the B-mode EUS images and with the final diagnosis obtained by EUS-guided fine needle aspiration (EUS-FNA) and/or by surgical pathology. An interobserver study was performed. RESULTS: The sensitivity and specificity of EUS elastography to differentiate benign from malignant pancreatic lesions are 92.3% and 80.0%, respectively, compared to 92.3% and 68.9%, respectively, for the conventional B-mode images. The sensitivity and specificity of EUS elastography to differentiate benign from malignant lymph nodes was 91.8% and 82.5%, respectively, compared to 78.6% and 50.0%, respectively, for the B-mode images. The kappa coefficient was 0.785 for the pancreatic masses and 0.657 for the lymph nodes. CONCLUSION: EUS elastography is superior compared to conventional B-mode imaging and appears to be able to distinguish benign from malignant pancreatic masses and lymph nodes with a high sensitivity, specificity and accuracy. It might be reserved as a second line examination to help characterise pancreatic masses after negative EUS-FNA and might increase the yield of EUS-FNA for lymph nodes.
AB - AIM: To evaluate the ability of endoscopic ultrasound (EUS) elastography to distinguish benign from malignant pancreatic masses and lymph nodes. METHODS: A multicenter study was conducted and included 222 patients who underwent EUS examination with assessment of a pancreatic mass (n = 121) or lymph node (n = 101). The classification as benign or malignant, based on the real time elastography pattern, was compared with the classification based on the B-mode EUS images and with the final diagnosis obtained by EUS-guided fine needle aspiration (EUS-FNA) and/or by surgical pathology. An interobserver study was performed. RESULTS: The sensitivity and specificity of EUS elastography to differentiate benign from malignant pancreatic lesions are 92.3% and 80.0%, respectively, compared to 92.3% and 68.9%, respectively, for the conventional B-mode images. The sensitivity and specificity of EUS elastography to differentiate benign from malignant lymph nodes was 91.8% and 82.5%, respectively, compared to 78.6% and 50.0%, respectively, for the B-mode images. The kappa coefficient was 0.785 for the pancreatic masses and 0.657 for the lymph nodes. CONCLUSION: EUS elastography is superior compared to conventional B-mode imaging and appears to be able to distinguish benign from malignant pancreatic masses and lymph nodes with a high sensitivity, specificity and accuracy. It might be reserved as a second line examination to help characterise pancreatic masses after negative EUS-FNA and might increase the yield of EUS-FNA for lymph nodes.
M3 - Journal article
C2 - 19340900
SN - 1007-9327
VL - 15
SP - 1587
EP - 1593
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 13
ER -