Epidermal biomarker levels differentiate lesional from non-lesional skin and show variation across anatomical locations in patients with atopic dermatitis

Jesper Grønlund Holm; Maja-Lisa Clausen; Tove Agner; Nicolai Skovbjerg Arildsen; Ivone Jakasa; Sanja Kezic; Simon Francis Thomsen

doi:10.1111/jdv.17070

Epidermal biomarker levels differentiate lesional from non-lesional skin and show variation across anatomical locations in patients with atopic dermatitis

Jesper Grønlund Holm, Maja-Lisa Clausen, Tove Agner, Nicolai Skovbjerg Arildsen, Ivone Jakasa, Sanja Kezic, Simon Francis Thomsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

2 Citationer (Scopus)

Abstract

We explored differences between lesional and non-lesional skin and anatomical variation in epidermal biomarker levels using stratum corneum (SC) tape strips in adult patients with atopic dermatitis (AD). SC tape strips from three distinct anatomical locations (upper extremity, trunk and lower extremity) and serum samples were collected from 25 adult patients with AD (mean age 34.8 years). Inflammatory cytokines in tape strips and serum, natural moisturizing factor (NMF), skin pH, and trans-epidermal water loss (TEWL) were measured. Disease severity was assessed using SCORing of Atopic Dermatitis (SCORAD) scores, respectively, global (overall) and local (lesion specific based on objective signs) SCORAD(1).

Originalsprog	Engelsk
Tidsskrift	Journal of the European Academy of Dermatology and Venereology : JEADV
Vol/bind	35
Udgave nummer	5
Sider (fra-til)	e325-e327
ISSN	0926-9959
DOI	https://doi.org/10.1111/jdv.17070
Status	Udgivet - 2021

Bibliografisk note

Adgang til dokumentet

10.1111/jdv.17070

Citationsformater

Holm, J. G., Clausen, M-L., Agner, T., Arildsen, N. S., Jakasa, I., Kezic, S., & Thomsen, S. F. (2021). Epidermal biomarker levels differentiate lesional from non-lesional skin and show variation across anatomical locations in patients with atopic dermatitis. Journal of the European Academy of Dermatology and Venereology : JEADV, 35(5), e325-e327. https://doi.org/10.1111/jdv.17070

Epidermal biomarker levels differentiate lesional from non-lesional skin and show variation across anatomical locations in patients with atopic dermatitis. / Holm, Jesper Grønlund; Clausen, Maja-Lisa; Agner, Tove ; Arildsen, Nicolai Skovbjerg; Jakasa, Ivone; Kezic, Sanja; Thomsen, Simon Francis.

I: Journal of the European Academy of Dermatology and Venereology : JEADV, Bind 35, Nr. 5, 2021, s. e325-e327.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Holm, JG, Clausen, M-L, Agner, T , Arildsen, NS, Jakasa, I, Kezic, S & Thomsen, SF 2021, 'Epidermal biomarker levels differentiate lesional from non-lesional skin and show variation across anatomical locations in patients with atopic dermatitis', Journal of the European Academy of Dermatology and Venereology : JEADV, bind 35, nr. 5, s. e325-e327. https://doi.org/10.1111/jdv.17070

Holm, Jesper Grønlund ; Clausen, Maja-Lisa ; Agner, Tove ; Arildsen, Nicolai Skovbjerg ; Jakasa, Ivone ; Kezic, Sanja ; Thomsen, Simon Francis. / Epidermal biomarker levels differentiate lesional from non-lesional skin and show variation across anatomical locations in patients with atopic dermatitis. I: Journal of the European Academy of Dermatology and Venereology : JEADV. 2021 ; Bind 35, Nr. 5. s. e325-e327.

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abstract = "We explored differences between lesional and non-lesional skin and anatomical variation in epidermal biomarker levels using stratum corneum (SC) tape strips in adult patients with atopic dermatitis (AD). SC tape strips from three distinct anatomical locations (upper extremity, trunk and lower extremity) and serum samples were collected from 25 adult patients with AD (mean age 34.8 years). Inflammatory cytokines in tape strips and serum, natural moisturizing factor (NMF), skin pH, and trans-epidermal water loss (TEWL) were measured. Disease severity was assessed using SCORing of Atopic Dermatitis (SCORAD) scores, respectively, global (overall) and local (lesion specific based on objective signs) SCORAD(1).",

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AU - Jakasa, Ivone

AU - Kezic, Sanja

AU - Thomsen, Simon Francis

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