Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres

D. M. Sørensen; H. Bostock; A. Abrahao; A. Alaamel; H. C. Alaydin; M. Ballegaard; E. Boran; B. Cengiz; M. de Carvalho; null Dunker; A. Fuglsang-Frederiksen; C. C. Graffe; K. E. Jones; M. Kallio; S. Kalra; C. Krarup; T. Krøigård; R. Liguori; T. Lupescu; S. Maitland; J. M. Matamala; M. Moldovan; J. Moreno-Roco; K. B. Nilsen; L. Phung; M. O. Santos; A. C. Themistocleous; H. Uysal; V. Vacchiano; R. G. Whittaker; L. Zinman; H. Tankisi

doi:10.1016/j.clinph.2023.04.008

Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres

D. M. Sørensen, H. Bostock, A. Abrahao, A. Alaamel, H. C. Alaydin, M. Ballegaard, E. Boran, B. Cengiz, M. de Carvalho, Dunker, A. Fuglsang-Frederiksen, C. C. Graffe, K. E. Jones, M. Kallio, S. Kalra, C. Krarup, T. Krøigård, R. Liguori, T. Lupescu, S. MaitlandJ. M. Matamala, M. Moldovan, J. Moreno-Roco, K. B. Nilsen, L. Phung, M. O. Santos, A. C. Themistocleous, H. Uysal, V. Vacchiano, R. G. Whittaker, L. Zinman, H. Tankisi^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

15 Citationer (Scopus)

Abstract

Objective: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans. Methods: Fifteen groups in 9 countries recorded CMAP scans twice, 1–2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP. Results: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA. Conclusions: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects. Significance: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans.

Originalsprog	Engelsk
Bogserie	Clinical Neurophysiology
Vol/bind	151
Sider (fra-til)	92-99
Antal sider	8
ISSN	1388-2457
DOI	https://doi.org/10.1016/j.clinph.2023.04.008
Status	Udgivet - 2023

Bibliografisk note

Funding Information:
This study was financially supported by the Lundbeck Foundation, Aage & Johanne Louis-Hansen Foundation, Dagmar Marshall's Foundation, Grosserer L. F. Foghts Foundation and The Jascha Foundation.

Publisher Copyright:
© 2023

Adgang til dokumentet

10.1016/j.clinph.2023.04.008

Citationsformater

Sørensen, D. M., Bostock, H., Abrahao, A., Alaamel, A., Alaydin, H. C., Ballegaard, M., Boran, E., Cengiz, B., de Carvalho, M., Dunker, Fuglsang-Frederiksen, A., Graffe, C. C., Jones, K. E., Kallio, M., Kalra, S., Krarup, C., Krøigård, T., Liguori, R., Lupescu, T., ... Tankisi, H. (2023). Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres. Clinical Neurophysiology, 151, 92-99. https://doi.org/10.1016/j.clinph.2023.04.008

Estimating motor unit numbers from a CMAP scan : Repeatability study on three muscles at 15 centres. / Sørensen, D. M.; Bostock, H.; Abrahao, A.; Alaamel, A.; Alaydin, H. C.; Ballegaard, M.; Boran, E.; Cengiz, B.; de Carvalho, M.; Dunker; Fuglsang-Frederiksen, A.; Graffe, C. C.; Jones, K. E.; Kallio, M.; Kalra, S.; Krarup, C.; Krøigård, T.; Liguori, R.; Lupescu, T.; Maitland, S.; Matamala, J. M.; Moldovan, M.; Moreno-Roco, J.; Nilsen, K. B.; Phung, L.; Santos, M. O.; Themistocleous, A. C.; Uysal, H.; Vacchiano, V.; Whittaker, R. G.; Zinman, L.; Tankisi, H.

I: Clinical Neurophysiology, Bind 151, 2023, s. 92-99.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Sørensen, DM, Bostock, H, Abrahao, A, Alaamel, A, Alaydin, HC, Ballegaard, M, Boran, E, Cengiz, B, de Carvalho, M, Dunker, Fuglsang-Frederiksen, A, Graffe, CC, Jones, KE, Kallio, M, Kalra, S, Krarup, C, Krøigård, T, Liguori, R, Lupescu, T, Maitland, S, Matamala, JM, Moldovan, M, Moreno-Roco, J, Nilsen, KB, Phung, L, Santos, MO, Themistocleous, AC, Uysal, H, Vacchiano, V, Whittaker, RG, Zinman, L & Tankisi, H 2023, 'Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres', Clinical Neurophysiology, bind 151, s. 92-99. https://doi.org/10.1016/j.clinph.2023.04.008

Sørensen, D. M. ; Bostock, H. ; Abrahao, A. ; Alaamel, A. ; Alaydin, H. C. ; Ballegaard, M. ; Boran, E. ; Cengiz, B. ; de Carvalho, M. ; Dunker ; Fuglsang-Frederiksen, A. ; Graffe, C. C. ; Jones, K. E. ; Kallio, M. ; Kalra, S. ; Krarup, C. ; Krøigård, T. ; Liguori, R. ; Lupescu, T. ; Maitland, S. ; Matamala, J. M. ; Moldovan, M. ; Moreno-Roco, J. ; Nilsen, K. B. ; Phung, L. ; Santos, M. O. ; Themistocleous, A. C. ; Uysal, H. ; Vacchiano, V. ; Whittaker, R. G. ; Zinman, L. ; Tankisi, H. / Estimating motor unit numbers from a CMAP scan : Repeatability study on three muscles at 15 centres. I: Clinical Neurophysiology. 2023 ; Bind 151. s. 92-99.

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title = "Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres",

abstract = "Objective: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans. Methods: Fifteen groups in 9 countries recorded CMAP scans twice, 1–2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP. Results: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA. Conclusions: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects. Significance: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans.",

keywords = "CMAP Scan, Motor unit number estimation, MScanFit, MUNE, Repeatability",

author = "S{\o}rensen, {D. M.} and H. Bostock and A. Abrahao and A. Alaamel and Alaydin, {H. C.} and M. Ballegaard and E. Boran and B. Cengiz and {de Carvalho}, M. and Dunker and A. Fuglsang-Frederiksen and Graffe, {C. C.} and Jones, {K. E.} and M. Kallio and S. Kalra and C. Krarup and T. Kr{\o}ig{\aa}rd and R. Liguori and T. Lupescu and S. Maitland and Matamala, {J. M.} and M. Moldovan and J. Moreno-Roco and Nilsen, {K. B.} and L. Phung and Santos, {M. O.} and Themistocleous, {A. C.} and H. Uysal and V. Vacchiano and Whittaker, {R. G.} and L. Zinman and H. Tankisi",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

doi = "10.1016/j.clinph.2023.04.008",

language = "English",

volume = "151",

pages = "92--99",

journal = "Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control",

issn = "1388-2457",

publisher = "Elsevier",

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TY - JOUR

T1 - Estimating motor unit numbers from a CMAP scan

T2 - Repeatability study on three muscles at 15 centres

AU - Sørensen, D. M.

AU - Bostock, H.

AU - Abrahao, A.

AU - Alaamel, A.

AU - Alaydin, H. C.

AU - Ballegaard, M.

AU - Boran, E.

AU - Cengiz, B.

AU - de Carvalho, M.

AU - Dunker, null

AU - Fuglsang-Frederiksen, A.

AU - Graffe, C. C.

AU - Jones, K. E.

AU - Kallio, M.

AU - Kalra, S.

AU - Krarup, C.

AU - Krøigård, T.

AU - Liguori, R.

AU - Lupescu, T.

AU - Maitland, S.

AU - Matamala, J. M.

AU - Moldovan, M.

AU - Moreno-Roco, J.

AU - Nilsen, K. B.

AU - Phung, L.

AU - Santos, M. O.

AU - Themistocleous, A. C.

AU - Uysal, H.

AU - Vacchiano, V.

AU - Whittaker, R. G.

AU - Zinman, L.

AU - Tankisi, H.

PY - 2023

Y1 - 2023

N2 - Objective: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans. Methods: Fifteen groups in 9 countries recorded CMAP scans twice, 1–2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP. Results: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA. Conclusions: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects. Significance: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans.

AB - Objective: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans. Methods: Fifteen groups in 9 countries recorded CMAP scans twice, 1–2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP. Results: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA. Conclusions: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects. Significance: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans.

KW - CMAP Scan

KW - Motor unit number estimation

KW - MScanFit

KW - MUNE

KW - Repeatability

U2 - 10.1016/j.clinph.2023.04.008

DO - 10.1016/j.clinph.2023.04.008

M3 - Journal article

C2 - 37236129

AN - SCOPUS:85159772140

VL - 151

SP - 92

EP - 99

JO - Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control

JF - Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control

SN - 1388-2457

ER -